Objective(s): Here, a reporter cell line containing two reporter vectors were developed, in order to monitor the Human T-Lymphotropic Virus type1(HTLV-1) infectivity and the cell viability simultaneously. Materials and Methods: The reporter cell line was constructed by stably transfected baby hamster's kidney cell line (BHK-21), with the genomes expressing two different reporters in separate pl...

The objective of the study was to evaluate the cytotoxic effects of aqueous extract of Cucumis melo fruit on human prostate cancer cell line (PC-3) using MTT and neutral red assays. The crude aqueous extract of C. melo was prepared by cold maceration method, filtered, concentrated and tested on PC-3 cell line. Dose-dependent cytotoxic activities were exhibited on human prostate carcinoma PC...

The objective of the study was to evaluate thecytotoxic effects of aqueous fruit extract of Cucumis melo in human prostate cancer cell line (PC-3) using MTTand neutral red assays. The crude aqueous extract of C.melo was prepared by cold maceration method, filtered,concentrated and tested on PC-3 cell line. Dose-dependent cytotoxic activitieswere exhibited by human prostate carcinoma PC-3 cell l...

In a systematic effort to identify a potent antiproliferative agent, four complexes of vanadium containing maltol and deferiprone ligands were synthesized and evaluated for their cytotoxic activity against five human and animal cancer cell lines, including human breast cancer cells (MCF-7), human cervix epithelial carcinoma (HeLa), human colon cancer cell line (HT-29), human leukemia cell line ...

background: urtica dioica is one of the medicinal herbs with many uses in treating various diseases. in some studies, its antiproliferative and apoptotic effects on cancer cell lines have been shown. therefore, the evaluation of u. dioica effect was performed on kg-1 cell line for acute myelogenous leukemia (aml) for the first time in this study. materials and methods: kg-1 cell line was treate...

background: tumour suppressor genes such as tp53, brca1 and rad51 are involved in dna repair and their malfunctions result in genomic instability and cancer. wild type (wt) tp53 binds to brca1and rad51 in vivo and in vitro. however, mutated tp53 in tumours can interfere with wt tp53 function. we studied how mutation of tp53 in mda-mb-468 cell line could affect its binding capacity and interfere...

Abstract Cities serve as hubs for various activities that necessitate comprehensive transportation connectivity. This study examines the decadal urban agglomeration patterns from 2001 to 2020 and critically assesses relationship between freeway developments, industrial relocation, population density in DFW (Dallas Fort Worth) metropolitan area. Landsat satellite imageries, US census, open-sourc...

herpes simplex virus types 1 (hsv-1) and 2 (hsv-2) are members of the herpesviridae family. about 40% to 80% of the world populations are infected with hsv and its prevalence is high in iran. the high prevalence of this virus in the community and the ability of the virus in causing fatal diseases among immunocompromised patients, have encouraged studies to be performed on hsv and suitable cell ...

Exalted, perhaps, in the wake of the World Trade Center attack, and suspecting, probably, that the American population would be satisfied with no response that fit within the limits of human comprehension, “someone, somewhere” in the Pentagon—the quotation is from Donald Rumsfeld— proposed “Infinite Justice” in late 2001 to designate the imminent campaign in Afghanistan. It was soon pointed out...

objective(s): glioblastoma multiforme (gbm) is one of the most lethal forms of human cancer and temozolomide (tmz) is currently part of the standard treatment for this disease. combination therapy using natural substances can enhance the anti-cancer activity of tmz. the purpose of this study was to evaluate the effect of tmz in combination with thymoquinone (tq) on human gbm cell line (u87mg). ...