Nabumetone is a nonacidic nonsteroidal anti-infl ammatory drug (NSAID) formulated as a pharmacologically inactive prodrug that becomes active only after absorption, predominantly in the small intestine, and through hepatic conversion to its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA). This metabolite is structurally similar to naproxen, and is a potent inhibitor of prostaglandin ...

AMAÇ: Bu çalışmada septorinoplasti yapılan hastalarda postoperatif analjezi için kullanılan non- opioid analjeziklerin tüketimine etkisinin karşılaştırılması amaçlanmıştır.
 GEREÇ VE YÖNTEM: Ocak 2019- Aralık 2019 tarihleri arasında cerrahisi geçiren hastaların kayıtları geriye dönük olarak incelenmiştir. Uygulanan yöntemi, analjezik ajan seçimi, tüketimleri, visuel analog skorları (VAS), ...

Acute and chronic bacterial prostatitis are considered infections which cumbersome to treat, due the limited available selection of effective antibiotics pharmacologically poor distribution in prostatic tissue. Furthermore, emergence novel antimicrobial resistance patterns, such as extended spectrum β‑lactamase (ESBL)‑producing Escherichia coli (E. coli) along with increasing ...

There has been a resurgence of interest in aerosolization of antibiotics for treatment of patients with severe pneumonia caused by multidrug-resistant pathogens. A combination formulation of amikacin-fosfomycin is currently undergoing clinical testing although the exposure-response relationships of these drugs have not been fully characterized. The aim of this study was to describe the individu...

Fosfomycin (FOS) is an antibiotic used in pig farms for treatment and prevention of infections caused by resistant bacteria during the post-weaning period. Antibiotics and non-toxic concentrations of mycotoxins, such as deoxynivalenol (DON) are frequently found in the diet of animals. These compounds can establish interactions in the intestinal tract, which could affect and/or modify the penetr...