Elimination of cytotoxic compounds in the early and later stages of drug discovery can help reduce the costs of research and development. Through the application of principal components analysis (PCA), we were able to data mine and prove that approximately 89% of the total log GI 50 variance is due to the nonspecific cytotoxic nature of substances. Furthermore, PCA led to the identification of ...

Received Jan 2, 2018 Revised Mar 9, 2018 Accepted Mar 24, 2018 In recent times complex software systems are continuously generating application and server logs for the events which had occurred in the past. These generated logs can be utilized for anomaly and intrusion detection. These log files can be used for detecting certain types of abnormalities or exceptions such as spikes in HTTP reques...

Cosmography is used in cosmological data processing order to constrain the kinematics of universe a model-independent way. In this paper, we first investigate effect ultraviolet (UV) and X-ray relation quasar on constraints. By fitting cosmographic parameters simultaneously, find that 4$\sigma$ deviation from constant cold dark matter ($\Lambda$CDM) model disappears. Next, utilizing Pantheon sa...

A genetic model-free method for the meta-analysis of genetic association studies is described that estimates the mode of inheritance from the data rather than assuming that it is known. For a bi-allelic polymorphism, with G as risk allele and g as wild-type, the genetic model depends on the ratio of the two log odds ratios, lambda = log OR(Gg)/log OR(GG), where OR(GG) compares GG with gg and OR...

An X-ray/Clincal medical image generally suffers from low contrast quality and degradations which vary from one region to another. Extraction of features in medical science and image processing is a matter of study and research. X-rays contain high redundancy, as far as background information is considered and in a way govern local image statistics. Contrast enhancement techniques based on visu...

aim : the aim of this study was to determine whether there is relation between body mass index and symptoms of gastro-esophageal reflux disease in our community using logit, probit and complementary log-log models. background : the most frequent statistical tool to address the relationship among a dichotomous response and other covariates is logistic regression. however logistic regression is f...