The synthesis of leukotrienes in human blood neutrophils chiefly relies on the activity of two enzymes, phospholipase A2 and 5-lipoxygenase (5-LO). In turn, the activation of the 5-LO requires the participation of a recently characterized membrane-bound protein, the 5-LO-activating protein (FLAP). In this study, we have investigated conditions under which FLAP expression in neutrophils may be m...

BACKGROUND Clinical experience suggests that granulation tissue may be inhibited by coverage with a musculocutaneous flap. We hypothesized that coverage of an open wound with a musculocutaneous flap would result in regression and apoptosis of the wound's granulation tissue. METHODS In the first experiment, 32 rats underwent excisional wounding; 16 underwent musculocutaneous flap coverage of t...

PURPOSE To describe stromal changes after a femtosecond laser laser-assisted in situ keratomileusis (LASIK) flap was created but not separated. DESIGN Case report. METHODS As part of a randomized paired-eye study comparing LASIK flap creation by a femtosecond laser to a mechanical microkeratome, a femtosecond laser flap was successfully created on one eye of one patient, but the flap was no...

In recent developments in the repair of large surgical defects where simple flap rotation may have been previously employed, myocutaneous flaps are being used because of functional advantages and to decrease the number of reconstructive procedures. The authors have employed myocutaneous flaps in 40 cases from January 1980 until April 1985 at Presbyterian Medical Center in Chonju. The primary di...

In 1952, Bjork created an inferior based tracheal flap through 2nd, 3rd and 4th tracheal ring which was later fixed to skin to secure the lumen of a tracheotomy tube. [1] Following this Bjork flap, many studies came which cited various complications or drawbacks for this flap. However, various studies have also reported no added risk and absence of complications associated with this. A recent g...

Okazaki fragments are initiated by short RNA/DNA primers, which are displaced into flap intermediates for processing. Flap endonuclease 1 (FEN1) and Dna2 are responsible for flap cleavage. Replication protein A (RPA)-bound flaps inhibit cleavage by FEN1 but stimulate Dna2, requiring that Dna2 cleaves prior to FEN1. Upon cleavage, Dna2 leaves a short flap, which is then cut by FEN1 forming a nic...

OBJECTIVES/HYPOTHESIS To describe a modification of the originally described superiorly based pharyngeal flap as a secondary operation to correct velopharyngeal insufficiency (VPI) in patients with nonsyndromic repaired cleft palate. STUDY DESIGN Prospective clinical trial at university medical center. METHODS Twenty-six patients with VPI after cleft palate repair underwent a modified poste...

OBJECTIVE Sacrococcygeal pilonidal sinus is common in young men and may recur over time after surgery. We investigated whether a factor exists that can aid in the determination of the preferred technique between the early Limberg flap and Karydakis flap techniques for treating recurrent pilonidal sinus. MATERIALS AND METHODS This prospective and randomized study enrolled 71 patients with recu...

BACKGROUND Breast reconstruction with deep inferior epigastric perforator (DIEP) flaps has gained considerable popularity due to reduced donor-site morbidity. Previous studies have identified the superficial venous system as the dominant outflow to DIEP flaps. DIEP flap venous congestion occurs if superficial venous outflow via the deep venous system is insufficient for effective flap drainage....

PURPOSE To evaluate programmed versus achieved laser-assisted in situ keratomileusis (LASIK) flap central thickness and investigate topographic flap thickness variability, as well as the effect of potential epithelial remodeling interference on flap thickness variability. PATIENTS AND METHODS Flap thickness was investigated in 110 eyes that had had bilateral myopic LASIK several years ago (av...