BACKGROUND Allergen-specific immunotherapy (SIT) is a highly effective treatment for allergic diseases, but the underlying mechanisms are unclear. In this study, we investigated the effects of cluster SIT with Dermatophagoides pteronyssinus (Der p) on IL-10-secreting type I T regulatory (Tr1) cells in Der p-sensitized patients with allergic rhinitis. METHODS This was a prospective randomized ...

Intermittent energy restriction may result in greater improvements in insulin sensitivity and weight control than daily energy restriction (DER). We tested two intermittent energy and carbohydrate restriction (IECR) regimens, including one which allowed ad libitum protein and fat (IECR+PF). Overweight women (n 115) aged 20 and 69 years with a family history of breast cancer were randomised to a...

Die Reduktion aromatischer Phosphane und Phosphanoxide mit Alkalimetallen in Ethern liefert farbige, paramagnetische Lösungen [1]. Die Charakterisierung der Radikale durch Elektronenspinresonanz ist wegen ihrer Reaktivität erschwert: Spaltung einer P-Aryl-Bindung kann zu SekundärRadikalionen mit Phosphor-Metall-Bindung [2, 3] oder zu weiteren Folgeprodukten [4, 5] führen, zur Erzeugung der prim...

A ggregationsfähigkeit verloren, und zwar im Falle von A lanin stärker als von Valin. W ichtig fü r die Frage der Tem peratursensitivität, d. h. den V erlust der Fähigkeit zu geordneter A ggre­ gation der P roteinuntereinheiten unter bestimmten Bedingungen, ist die Kom bination einer bestimmten A m inosäure m it einer bestimmten Position inner­ halb der P roteinkette. Es ist für diese Frage neb...

BACKGROUND Der f 7 is the group 7 allergen from the dust mite Dermatophagoides farinae, homologous to the major allergen Der p 7 from D. pteronyssinus. Monoclonal antibody that bind to residues Leu48 and Phe50 was found to inhibit IgE binding to residue Asp159, which is important for the cross-reactivity between Der f 7 and Der p 7. METHODOLOGY/PRINCIPAL FINDINGS Here, we report the crystal s...

Enzymology of the Liver Frontiers of Gastrointestinal Research Vol. 2 Series Editor: LEO VAN DER RBIS, San Francisco, Calif. Editorial Board: R. LAMBERT, Lyon; S. LORBER, Philadelphia, Pa.; D. W. PIPER, Crows Nest, N.S.W.; H. SHIRAKABE, Tokyo; K.B. TAYLOR, Palo Alto, Calif.; N. ZLLNER, Munich S. Karger Basel' Mnchen . Paris' London' New York' Sydney Enzymology of the Liver Editor: LEO VAN DER R...

Random heptapeptide T7 and random 12mer M13 phage libraries were employed to identify mimotopes binding to monoclonal antibodies (MAb) specific to house dust mite. After selection of bound phage by bio-panning and determination of binding specificity, DNA of selected bound phages was amplified, sequenced and aligned for peptide similarity. Eight mimotopes which were partially matched with Der f...