Suicide, this very complex and multicausal human behaviour, is related to several psychiatric-medical, psychosocial and demographic suicide risk factors. Psychological autopsy studies consistently show that over 90 percent of suicide victims have at least one (mostly untreated) current major mental disorder, most frequently major depressive episode (56-87%) substance-related disorders (26-55%) ...

Zusammenfassung Hintergrund Studierende in Deutschland weisen seltener einen guten subjektiven Gesundheitszustand und häufiger eine depressive Symptomatik auf als die 18- bis 29-jährige Allgemeinbevölkerung. Ziel Fragestellung der Befragung ist Analyse des Gesundheitszustands, -verhaltens Interessen an Maßnahmen Gesundheitsförderung Prävention sowie dabei vorliegenden Unterschiede bei Studieren...

Platelet monoamine Oxidase (MAO) activity was estimated in 30 depressed patients treated with Imipramine or EGT over a period of 5 weeks and pretreatment and post treatment values were compared. Imipramine and ECT caused significant reduction of platelet MAO, which after 7 days washout period comes to the pretreatment level while subjects clinical status l remained unchanged. The percentage blo...

We report the utilization of a very sensitive radioimmunoassay for plasma B-END, which has enabled us to examine the suppressibility of B-END-like material, under dexamethasone challenge, on a population of depressed patient~. We have found that B-END-like material in plasma is suppressed by dexamethasone in a psychiatric control population, whereas suppression is less likely in endogenously de...

Sixty patients of endogenous depression and thirty normal controls were studied to find out the relationship of post dexamethasone plasma Cortisol levels (PDPC) and clinical improvement of endogenous depression inpatients treated with electroconvulsive therapy and imipramine. The PDPC levels in both the group of patients showed significant decrease with clinical improvement (Pre and post treatm...

The risk of suicide among the first-degree relatives of 195 schizophrenic and 315 manic-depressive patients in a long-term study was estimated. The findings demonstrate a higher risk of suicide among relatives of psychiatric patients in comparison with relatives of surgical controls. Male relatives had a higher risk of suicide than female relatives. When suicide risk in the relatives was analyz...

AMONG psychotic patients the manic-depressive has probably gained most from recent advances in treatment. In spite of this improving outlook, there has been a disappointingly small increase in our understanding of the nature of the disease itself. A real contribution to this understanding is made in this report of the epidemiology of manic-depressive psychosis in a Swedish county between 1919 a...

Background Elevated circulating cytokines leading to microglia activation have been implicated in the increased risk for Alzheimer’s Disease (AD) depression. However, correlations between peripheral and central inflammatory markers inconclusive. Additionally, only some depressives show evidence of inflammation. Microglia can assume anti-inflammatory states via signaling their TREM2 receptor wit...

The link between borderline personality disorder (BPD) and the affective disorders remains controversial. The aim of this study was to examine the relationships between BPD and major depression (MD) from the perspective of sleep parameters and to contribute to the characterisation of the sleep-EEG in BPD. We compared 20 off-medication BPD in-patients without co-existing MD with 20 sex- and age-...

THERE IS A TRADITION OF EXCEPTIONAL difficulty in the psychoanalysis or other psychotherapy of depressives. Edith Jacobson (1954) spoke of a more intensive affective involvement with them. She referred to intervening with a "spontaneous gesture of kindness or even a brief expression of anger, " but wisely added, "... since these patients are frequently very provocative and exasperating, such a ...