نتایج جستجو برای: dendritic cell targeting
تعداد نتایج: 1805126 فیلتر نتایج به سال:
Abstract Immune regulator receptors play a crucial role in immune homeostasis by balancing activating vs inhibitory responses and are distributed across cells of myeloid lymphoid lineages. Inhibitory contain Receptor Tyrosine-based Motifs (ITIM) suppress response via SH2 domain-containing protein tyrosine phosphatases (SHP2). Dendritic Cell (DCIR) is C-type lectin receptor expressed on monocyte...
The development of Inflammatory bowel disease (IBD) is driven by excessive production pro-inflammatory cytokines including TNF-α, IL-12, and IL-23. This notion supported the remarkable clinical success biologics targeting these cytokines. Recognition cell wall components derived from intestinal bacteria Toll-like receptors (TLRs) induces macrophages dendritic cells in human IBD experimental col...
Abstract Dendritic cell (DC) activation via pathogen-associated molecular patterns (PAMPs) is critical for antigen presentation and development of adaptive immune responses, but the stochastic distribution DC responses to PAMP signaling, especially during initial stages activation, poorly understood. In this study, we isolate a unique subpopulation preferential phagocytosis microparticles (MPs)...
Crohn's disease (CD) is an inflammatory disease of the gastrointestinal tract (GIT) tract and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of inflammatory bowel disease patients and the role of bacteria such as Mycobacterium avium paratuberculosis in CD. Apart from different therapeutic approaches for treating CD, developm...
A properly functioning adaptive immune system signifies the best features of life. It is diverse beyond compare, tolerant without fail, and capable of behaving appropriately with a myriad of infections and other challenges. Dendritic cells are required to explain how this remarkable system is energized and directed. I frame this article in terms of the major decisions that my colleagues and I h...
Transfection with synthetic mRNA is a safe and efficient method of delivering antigens to dendritic cells for immunotherapy. Targeting antigens to the lysosome can sometimes enhance the CD4+ T-cell response. We transfected antigen-presenting cells (APCs) with mRNA encoding Gag-p24 and cytoplasmic, lysosomal, and secreted forms of Nef. Antigen-specific cytotoxic T cells were able to lyse the maj...
Targeting of antigens to immature dendritic cells has been shown to result in antigen-specific T-cell tolerance in vivo. In the INS-HA/TCR-HA transgenic mouse model for type 1 diabetes, we tested the potential of the dendritic cell-specific monoclonal antibody DEC-205 conjugated to the hemagglutinin (HA) antigen (DEC-HA) to prevent disease onset. Whereas untreated INS-HA/TCR-HA mice all develop...
Stereotypical connections between olfactory sensory neuron axons and mitral cell dendrites in the olfactory bulb establish the first synaptic relay for olfactory perception. While mechanisms of olfactory sensory axon targeting are reported, molecular regulation of mitral cell dendritic growth and refinement are unclear. During embryonic development, mitral cell dendritic distribution overlaps w...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید