The current study was aimed to develop a targeted dendrimer formulation of 3, 4-difluorobenzylidene curcumin (CDF) and evaluate its potential in CD44 targeted therapy for pancreatic cancer. Using amine terminated fourth generation poly(amidoamine) (PAMAM) dendrimer nanocarrier and hyaluronic acid (HA) as a targeting ligand, we engineered a CD44-targeted PAMAM dendrimer (HA-PAMAM) formulation of...

UNLABELLED Mechanisms underlying the in vitro cytotoxicity of Polyamidoamine nano-dendrimers in human keratinocytes are explored. Previous studies demonstrated a systematic, dendrimer-generation-dependent cytotoxicity, oxidative stress, and genotoxicity. The emerging picture is of dendrimer endocytosis, endosomal rupture and subsequent mitochondrial attack and cell death. To understand the unde...

Dendrimers comprise a category of branched materials with diverse functions that can be constructed with defined architectural and chemical structures. When decorated with bioactive ligands made of peptides and saccharides through peripheral chemical groups, dendrimer conjugates are turned into nanomaterials possessing attractive binding properties with the cognate receptors. At the cellular le...

Gene transfer to the lung can be achieved via either the airway or the pulmonary vasculature. We evaluated gene transfer and expression by intravascular and endobronchial routes, using DNA complexed with G9 PAMAM dendrimer or naked plasmid DNA. Intravascular tail vein delivery of dendrimer-complexed pCF1CAT plasmid resulted in high levels of transgene expression in the lung at 12 and 24 hr, fol...

supramolecule self assembly polyamidoamine (pamam) dendrimer refers to the chemical systems made up of a discrete number of assembled molecular subunits or components. these strategies involve the covalent assembly of hierarchical components reactive monomers, branch cells or dendrons around atomic or molecular cores according to divergent/convergent dendritic branching principles, systematic f...

PURPOSE Dendrimeric polyguanidilyated translocators (DPTs) are nanosized novel dendrimers that efficiently translocate molecules across biological barriers. The purpose of this study was to develop a DPT that could serve as an ophthalmic delivery vehicle for gatifloxacin and to evaluate its in vitro and in vivo delivery after topical application. METHODS The gatifloxacin (GFX) solubility-enha...

a graph that contains a hamiltonian cycle is called a hamiltonian graph. in this paper wecompute the first and the second geometric – arithmetic indices of hamiltonian graphs. thenwe apply our results to obtain some bounds for fullerene.

a connected graph g is said to be neighbourly irregular graph if no two adjacent vertices of g have same degree. in this paper we obtain neighbourly irregular derived graphs such as semitotal-point graph, k^{tℎ} semitotal-point graph, semitotal-line graph, paraline graph, quasi-total graph and quasivertex-total graph and also neighbourly irregular of some graph products.

Specific and robust targeting of pathogenic cells would represent a major advance in treatment eye diseases including diabetic retinopathy. In article number 2000181 Rangaramanujam M. Kannan, Elia J. Duh co-workers use the corticosteroid triamcinolone conjugated to surface PAMAM-dendrimers, which are tree-like branching polymeric nanoparticles. This dendrimer-triamcinolone conjugate selectively...

abstract. suppose g is an nvertex and medge simple graph with edge set e(g). an integervalued function f: e(g) → z is called a flow. tutte was introduced the flow polynomial f(g, λ) as a polynomial in an indeterminate λ with integer coefficients by f(g,λ) in this paper the flow polynomial of some dendrimers are computed.