نتایج جستجو برای: demyelinating disease
تعداد نتایج: 1495276 فیلتر نتایج به سال:
Association between demyelinating disease and autoimmune rheumatic disease in a pediatric population
Although myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune demyelinating disease, it may occur as a paraneoplastic syndrome in rare instances. A 80-year-old woman presented with paresthesia and weakness of four extremities for 10 days. Spine magnetic resonance imaging showed longitudinally extensive transverse myelitis. Laboratory tests revealed positive M...
Symptomatic retrochiasmatic lesions due to demyelinating disease are rare in multiple sclerosis. The most common cause of visual disturbance in multiple sclerosis is optic neuritis which typically presents with pain around the eye that worsens with movement, dyschromatopsia and monocular decreased visual acuity. We describe a patient who presented with bilateral blurry vision who was found to h...
Multiple sclerosis (MS) is a demyelinating process involving mainly the white matter of central nervous system. The clinical diagnosis generally rests on two features of the illness: A. A history of fluctuations in the clinical course. B. A physical examination consistent with that of multiple lesionsjinllheiwhite matter o,f the central nervous system. No specific laboratory test is cur...
Theiler's murine encephalomyelitis virus is an endemic murine pathogen that induces a demyelinating disease of the central nervous system in susceptible mouse strains. The disease is characterized by central nervous system mononuclear cell infiltration and presents as chronic, progressive paralysis. The expression of CC and C-x-C chemokines in the central nervous system of Theiler's murine ence...
Multiple sclerosis is a chronic autoimmune demyelinating disease, one of the most common symptoms which are urinary disorders. The review article provides information on epidemiology, pathogenesis, symptoms, clinical course and diagnostic features neurogenic dysfunctions lower tract in patients with multiple sclerosis. Attention drawn to need for early diagnosis dysfunctions, predetermines time...
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the human central nervous system (CNS). Neurotropic demyelinating strain of MHV (MHV-A59 or its isogenic recombinant strain RSA59) induces MS-like disease in mice mediated by microglia, along with a small population of T cells. The mechanism of demyelination is at least in part due to microglia-mediated myelin stripping, with s...
Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disor...
A prospective study was undertaken to evaluate the potential of Gd-DTPA-enhanced MR to differentiate active from inactive demyelinating lesions of the cervical spinal cord. Five patients with elongated high-signal-intensity lesions in the cervical cord on long TR/TE spin-echo MR images and a clinical suspicion of demyelinating disease had MR before and after IV Gd-DTPA. Delayed contrast enhance...
BACKGROUND Action myoclonus-renal failure syndrome is a hereditary form of progressive myoclonus epilepsy associated with renal failure. It is considered to be an autosomal-recessive disease related to loss-of-function mutations in SCARB2. We studied a German AMRF family, additionally showing signs of demyelinating polyneuropathy and dilated cardiomyopathy. To test the hypothesis whether isolat...
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