We present a robust and efficient method for the two-way coupling between particle-based fluid simulations and infinitesimally thin solids represented by triangular meshes. Our approach is based on a hybrid method that combines a repulsion force approach with a continuous intersection handling to guarantee that no penetration occurs. Moreover, boundary conditions for the tangential component of...

Many vertebrate small nuclear RNA gene promoters contain an SPH motif in their distal control regions that can confer transcriptional stimulation by RNA polymerase II or RNA polymerase III. Using the human U6 gene SPH motif as a probe, we isolated a cDNA encoding human SPH-binding factor (hSBF) from a HeLa cell expression library. The coding region of hSBF is almost identical to ZNF143, a 626 a...

The bioactive molecule sphingosine 1-phosphate (S1P) is abundantly stored in platelets and can be released extracellularly. However, although they have high sphingosine (Sph) kinase activity, platelets lack the de novo sphingolipid biosynthesis necessary to provide the substrates. Here, we reveal a generation pathway for Sph, the precursor of S1P, in human platelets. Platelets incorporated extr...

Independent of their etiology, all chronic liver diseases ultimately lead to liver cirrhosis, which is a major health problem worldwide. The underlying molecular mechanisms are still poorly understood and no efficient treatment strategies are available. This paper introduces the sinusoidal pressure hypothesis (SPH), which identifies an elevated sinusoidal pressure (SP) as cause of fibrosis. SPH...

The Support Architecture for Large-Scale Subsurface Analysis (SALSSA) provides an extensible framework, sophisticated graphical user interface (GUI), and underlying data management system that simplifies the process of running subsurface models, tracking provenance information, and analyzing the model results. The SALSSA software framework is currently being applied to validating the Smoothed P...

The Smoothed Particle Hydrodynamics (SPH) numerical method was introduced by Lucy [20] and Gingold and Monaghan [21]. Its first application was in the field of star formation, where it was used to study whether or not a rapidly-rotating polytrope could undergo fission to form a close binary system [20, 22]. Since this initial application, SPH has been widely used in the study of star formation,...

Chemical investigation of Sophora japonica seeds resulted in the isolation of seven metabolites identified as: genistin (1), sophoricoside (2), sophorabioside (3), sophoraflavonoloside (4), genistein 7,4'-di-O-β-D-glucopyransoide (5), kaempferol 3-O-α-L-rhamnopyranosyl(1 → 6)β-D-glucopyranosyl(1 → 2)β-D-glucopyranoside (6) and rutin (7). Compounds 1, 2 and 5 showed significant estrogenic prolif...

We present a robust and efficient method for simulating Lagrangian solid-fluid coupling based on new operator splitting strategy. use variational formulations to approximate fluid properties interactions, introduce unified two-way formulation SPH fluids FEM solids using interior point barrier-based frictional contact. split the resulting optimization problem into phase solid-coupling novel time...

This paper presents a novel coupling between the Total Lagrangian and Eulerian formulations of Smooth Particle Hydrodynamics (SPH) method. It is implemented such that formulation can adaptively convert to an (referred as AdapTLE in this work) applied high-velocity impact problems. The makes use mixed kernel-and-gradient correction scheme, which order improve consistency conserve momentum. Addit...