نتایج جستجو برای: deirdre shauna lynch
تعداد نتایج: 4046 فیلتر نتایج به سال:
Micheline Labelle, Geneviève Turcotte, Marianne Kempeneers et Deirdre Meintel, Histoires d’immigrées
OBJECTIVE To evaluate the effectiveness of the uterine compression suture (B-Lynch and modified B-Lynch suture) in avoiding hysterectomy in cases ofpostpartum hemorrhage and in eliminating the need for surgical intervention to arrest bleeding. MATERIAL AND METHOD This was a retrospective study using data all from women giving birth in Rajavithi Hospital between July 2010 and June 2012. Data w...
Recently, we identified 3' end deletions in the EPCAM gene as a novel cause of Lynch syndrome. These truncating EPCAM deletions cause allele-specific epigenetic silencing of the neighboring DNA mismatch repair gene MSH2 in tissues expressing EPCAM. Here we screened a cohort of unexplained Lynch-like families for the presence of EPCAM deletions. We identified 27 novel independent MSH2-deficient ...
BACKGROUND A possible role for prostate cancer in Lynch syndrome has been debated based on observations of mismatch-repair defective tumors and reports of an increased risk of prostate cancer in mutation carriers. Potential inclusion of prostate cancer in the Lynch syndrome tumor spectrum is relevant for family classification, risk estimates and surveillance recommendations in mutation carriers...
Since the recognition of Lynch syndrome, which confers a high risk of colorectal, uterine, and other cancers, approaches to its diagnosis have included a family history of associated cancers and web-based algorithms. Identification of causative genes now allows a precise diagnosis, thus focusing present efforts on who should have genetic testing. Testing for cancer tissue changes can determine ...
R isk stratification is essential for designing efficacious and cost effective colon cancer screening programmes. One of the most important risk factors for colorectal cancers (CRC) is an inherited predisposition, implicated in 20% of all cases. The spectrum of genetic susceptibility ranges from the low penetrance mutations that modestly increase the colon cancer risk (for example, I 1307K) to ...
Lynch syndrome, also referred to as hereditary non-polyposis colorectal cancer (HNPCC), accounts for somewhere between 2 and 5% of all CRC. It has been shown that Lynch syndrome (LS) is a result of germline mutations in genes involved in DNA mismatch repair (MMR) MSH2, MLH1, MSH6, and PMS2, whereas as HNPCC refers to families that adhere to the Amsterdam criteria or iterations of it. More recen...
Pluralism, according to Michael P. Lynch, is the thesis that there are or can be more than one true story of the world; there can be incompatible but equally acceptable accounts of some subject matter.’ The opposite view, absolutism, states that there can be only one true story about how the world is. In our ordinary lives both theses have intuitive pull. Most of us are ready to say that there ...
Lynch syndrome caused by constitutional mismatch‑repair defects is one of the most common hereditary cancer syndromes with a high risk for colorectal, endometrial, ovarian and urothelial cancer. Lynch syndrome is caused by mutations in the mismatch repair (MMR) genes i.e., MLH1, MSH2, MSH6 and PMS2. After 20 years of genetic counseling and genetic testing for Lynch syndrome, we have compiled th...
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