PURPOSE To noninvasively assess bone marrow microcirculation before and after therapy in patients with newly diagnosed multiple myeloma with dynamic contrast-enhanced MRI (DCE-MRI). EXPERIMENTAL DESIGN Ninety-six patients received DCE-MRI before and after primary treatment for newly diagnosed multiple myeloma. For the 91 evaluable patients, treatment consisted of high-dose therapy (HDT) with ...

Dynamic contrast-enhanced (DCE) MRI is a powerful tool that maps the spatial distribution of vascular parameters in the brain, including blood-brain-barrier (BBB) permeability, interstitial transit times, and interstitial volume. DCE-MRI is widely used to assess BBB leakage in brain tumors and multiple sclerosis lesions, and it has potential applications in Alzheimer’s dementia, vascular cognit...

The efficacy of polydisulfide-based biodegradable macromolecular contrast agents for characterizing tumor angiogenesis was investigated in a mouse model using dynamic contrast-enhanced MRI (DCE-MRI). Biodegradable macromolecular MRI contrast agents, gadopentetate dimeglumine (Gd-DTPA) cystamine copolymers (GDCC), and Gd-DTPA cystine copolymers (GDCP), with molecular weights of 20 and 70 kDa wer...

OBJECTIVES We evaluated whether delayed contrast-enhanced magnetic resonance imaging (DCE-MRI) using an extracellular contrast agent could predict improvement of dysfunctional but viable myocardium after acute reperfused myocardial infarction (MI). BACKGROUND The transmural extent of hyperenhancement at DCE-MRI has been related to improvement of function in reperfused MI. However, evidence is s...

I note the short communication by Turkbey and Choyke providing a succinct summary of the updated PI-RADS system for prostate MRI acquisition and interpretation in the September-October 2015 issue of Diagnostic and Interventional Radiology. (1). An interesting argument has also been presented against the routine use of dynamic contrast-enhanced (DCE) sequences suggested therein for multiparametr...

AIM To investigate the capability and diagnostic accuracy of diffusion-weighted imaging (DWI) in differentiating benign from malignant breast lesions using 3 T magnetic resonance imaging (MRI). MATERIALS AND METHODS Women with suspicious or indeterminate breast lesions detected at MRI, mammogram and/or ultrasound were recruited for dynamic contrast-enhanced (DCE)-MRI and DWI prior to their bi...

Introduction: Dynamic Contrast-enhanced MRI (DCE-MRI) consists of a series of rapid T1-weighted imaging (seconds per scan; tens of scans) performed before, during, and after the administration of an intravenous contrast agent that reduces the T1 value of blood and thereby enhances the signal intensity. It has become a useful tool to study the perfusion, permeability and angiogenesis property in...

Background Dynamic gadolinium contrast-enhanced (DCE) vessel wall MRI has recently been used to compute a set of model-based contrast kinetic parameters (e.g. K and Vp) that can well characterize the extent of inflammation in carotid plaques [1,2]. However, no studies have shown its feasibility in coronary artery wall, presumably due to the technical challenges in imaging such a constantly-movi...

OBJECTIVE The purpose of this study is to evaluate the utility of T2-weighted imaging, dynamic contrast-enhanced MRI (DCE-MRI), and diffusion-weighted imaging (DWI) for detecting prostate cancer in patients with total serum prostate-specific antigen (PSA) levels of 4-10 ng/mL, which is referred to as the "gray zone." MATERIALS AND METHODS Fifty patients with gray-zone PSA levels underwent MRI...

Introduction. Dynamic contrast-enhanced (DCE) MRI and the fitting of pharmacokinetic (PK) models to the resulting image data has been widely used in oncology to investigate tumour vascularity, particularly in conjunction with treatment response. Despite the improved SNR offered by 3T MRI systems, to date the majority of these studies have been performed at 1.5T. This may be due in part to conce...