The acquisition of autosomal fertility genes has been proposed to be an important process in human Y chromosome evolution. For example, the Y-linked fertility factor DAZ (Deleted in Azoospermia) appears to have arisen after the transposition and tandem amplification of the autosomal DAZH gene. The Drosophila melanogaster Y chromosome contains tandemly repeated Su(Ste) units that are thought to ...

The human DAZL1 gene (known also as DAZH or DAZLA) is the autosomal homologue of the Y-chromosomal DAZ gene which has been found to be deleted in azoospermic males. Evidence suggests that the role of DAZL1 may not be restricted to spermatogenesis, but may include oogenesis as well. In order to study the function of human DAZL1 gene in the ovary, we observed its expression pattern during embryon...

BACKGROUND Deleted in AZoospermia-like (DAZL) is an autosomal homologue of Y chromosome-linked DAZ gene located on chromosome 3p24. DAZL is only expressed in the gonads and is critical to germ cell development in different species. However, the regulation of DAZL has not been explored. METHODS Reporter assays, electrophoretic mobility shift assays, supershift assays and bisulfate sequencing w...

Simultaneous DMSP F7 and Viking satellite measurements of the dawnside high-latitude auroral energy electron and ion precipitation show that the region of the low and middle altitude auroral precipitation consists of three characteristic plasma regimes. The recommendation of the IAGA Working Group IIF/III4 at the IAGA Assembly in Boulder, July 1995 to decouple the nomenclature of ionospheric po...

Fremdsprachige Literatur impliziert bei Lernenden durchaus noch große Berührungsängste auch im fortgeschrittenen Stadium. Im Sinne einer sprachlichen und kulturellen Bildung sollte auf die Lektüre in der Originalsprache keinesfalls verzichtet werden. So wird insbesondere deutschen Kulturraum das Vorlesen als Grundlage zur Entwicklung von Lesemotivation Lesesozialisation eingesetzt. Das trägt be...

OBJECTIVE To test the diagnostic efficiency of a gene-specific, five-marker screening strategy for the detection of Y chromosome deletions. DESIGN Prospective case study. SETTING University genetics laboratory and reproductive clinics. PATIENT(S) Six hundred twenty-seven infertile men and 212 fertile men. INTERVENTION(S) Peripheral blood samples were screened for Y chromosome deletions ...