A non-lethal, hypoxic conditioning stimulus has been shown by Rising and D'Alecy to increase hypoxic survival time in mice. To determine if endogenous opioids alter the hypoxic conditioning-induced increase in hypoxic survival time, we administered naloxone (0.1, 1.0 mg/kg i.p.) or saline (0.3 ml i.p.) 5 min prior to conditioning. Sixty percent of the mice received the hypoxic conditioning stim...

Extensive evidence indicates that the septum plays a predominant role in fear learning, yet the direction of this control is still a matter of debate. Increasing data suggest that the medial (MS) and lateral septum (LS) would be differentially required in fear conditioning depending on whether a discrete conditional stimulus (CS) predicts, or not, the occurrence of an aversive unconditional sti...

The dorsal and ventral subregions of the hippocampus likely play dissociable roles in some forms of learning. For example, we have previously demonstrated that temporary inactivation of ventral, but not dorsal, hippocampus dramatically impaired the acquisition of trace fear conditioning, while temporary inactivation of dorsal, but not ventral, hippocampus impaired spatially guided reinforced al...

BACKGROUND Physical conditioning programs aim to improve work status for workers on sick leave. This is an update of a Cochrane Review (Work conditioning, work hardening and functional restoration for workers with back and neck pain) first published in 2003. OBJECTIVES To compare the effectiveness of physical conditioning programs in reducing time lost from work for workers with back pain. ...

This study addresses the ill-conditioning problem of the memory polynomial (MP) model with application to the predistortion of highly non-linear power amplifiers with memory effects. A resource-efficient lattice-based MP structure built using the cascade of a MP generator and a lattice predictor is proposed to overcome the ill-conditioning of the MP’s data matrix. The proposed model performance...

The ability to differentiate danger and safety through associative processes emerges early in life. Understanding the mechanisms underlying associative learning of threat and safety can clarify the processes that shape development of normative fears and pathological anxiety. Considerable research has used fear conditioning and extinction paradigms to delineate underlying mechanisms in animals a...

Observers detected briefly pulsed sine-wave gratings presented with various asynchronies before, during or after a 700 msec conditioning flash. Although the conditioning flash raised increment thresholds for detection of both low and high spatial frequency gratings, shapes of the masking curves differed. Curves for low spatial frequency gratings exhibited peaks at the conditioning field on and ...

One of the jobs of a circuit designer is to build a measurement system that provides valid input-to-output data as defined by the system requirements over a given frequency range. The four possible elements of a signal path include a gain/signal conditioning cell, an anti-aliasing filter, an analog-to-digital converter (ADC) and a digital processing block. Figure 1 shows this type of system wit...

background: connective tissue attachment following periodontal regenerative surgery is directly related to the attachment of fibrin clot on to the root surface during early wound healing events. the adhesion of fibrin clot to the root surface affected by periodontal disease depends on the biologic acceptance of the root surface which can be accomplished by various root conditioning procedures d...

introduction: allogeneic hematopoietic cell transplantation (hsct) is the only therapeutic modality capable of correcting the hematologic manifestations of fanconi anemia (fa). the development  of well  tolerated,  immunosuppressive  conditioning  regimens  for fa patients  undergoing hsct has proven to be a rather challenging task for hematologists. methods: we analyzed the outcome of 30 fa pa...