We present a technique for fabricating hydrophobic drug nanoparticles using a microfluidic spray dryer. The nanoparticles are formed by evaporative precipitation of the spray in air at room temperature. Using danazol as a model drug, amorphous nanoparticles are yielded with narrow size distribution, 20-60 nm in diameter. As the device geometry allows us to inject two separate solvent streams, t...

n engl j med 364;1 nejm.org january 6, 2011 86 replacement therapy in patients with severe hereditary angioedema refractory to danazol prophylaxis. Transfusion 2009;49: 1987-95. 2. Bowen T, Cicardi M, Farkas H, Bork K, et al. 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema. Allergy Asthma Clin Immunol 2010;6:24. 3. Longhurst HJ, Farkas H...

The main haematological manifestations seen in patients with antiphospholipid antibodies (aPL) are thrombocytopenia, usually mild, and haemolytic anaemia with a positive Coombs test. Owing to the shared characteristics with idiopathic thrombocytopenic purpura, similar rules are followed in the treatment of these cytopenias. Two patients with severe aPL associated cytopenias, who required splene...

at 4 mg/dl (Normal = 15-35). With danazol 200-300 mg daily, his episodes of angioedema decreased. A few years later, when he developed laryngeal oedema, his condition was not recognised resulting in delay in definitive therapy. Fortunately, he recovered with an emergency tracheostomy. He later had another episode of laryngeal oedema which was arrested with fresh frozen plasma and tranexamic aci...

ASBMBS Guidelines/Statements ASMBS Position Statement on Postprandial Hyperinsulinemic Hypoglycemia after Bariatric Surgery Dan Eisenberg, M.D., M.S.*, Dan E. Azagury, M.D., Saber Ghiassi, M.D., Brandon T. Grover, D.O., Julie J. Kim, M.D. Department of Surgery, Stanford School of Medicine, Stanford, California Department of Surgery, Palo Alto VA Health Care System, Palo Alto, California Section...