Low-molecular-weight heparins (LMWHs) are used in clinical practice as anticoagulants since they enhance the antithrombin III (ATIII) inhibitory action against coagulation enzymes. This work is focused on effects ATIII protein induced by interaction with LMWHs. In particular, thermal stability modifications presence of Dalteparin, Enoxaparin and Tinzaparin their fractionated portions were inves...

BACKGROUND/AIMS Venous thromboembolism (VTE) is the most common complication after major joint surgery. VTE can easily develop into pulmonary embolism (PE), leading to cardiopulmonary dysfunction or sudden death. We aimed to comprehensively analyse the thromboprophylactic drugs that are used to prevent thrombosis and reduce bleeding risk. METHODS We searched the PubMed, EMBASE, and Cochrane d...

CASE HISTORIES Case 1: Massive Baker’s cyst presenting as a deep venous thrombosis (fig 1) A 68 year old woman presented to the accident and emergency department describing a three day history of acute left calf pain and swelling associated with severe difficulty in weight bearing. She had been previously diagnosed with hypertension, peptic ulcer disease, and had had seronegative rheumatoid art...

BACKGROUND Anticoagulants, e.g. low-molecular weight heparins (LMWHs) and acetylsalicylic acid (ASA) are prescribed to women at risk for pregnancy complications that are associated with impaired placentation and placental hypoxia. Beyond their role as anticoagulants these compounds exhibit direct effects on trophoblast but their impact on placental function is unknown. The amino acid transport ...

A 48-hour course of intravenous unfractionated heparin (UFH) is the standard of treatment in conjunction with fibrin-specific thrombolysis in ST-elevation myocardial infarction (STEMI). In recent trials, the efficacy and safety of in-hospital administration of subcutaneous low-molecular-weight heparins (LMWH), previously proven effective in non-ST-elevation acute coronary syndromes, have been i...

As part of a more extensive investigation on structural features of different low-molecular-weight heparins (LMWHs) that can affect their biological activities, Enoxaparin, Tinzaparin and Dalteparin were characterised with regards to the distribution of different chain length oligosaccharides as determined by size-exclusion (SE) chromatography, as well as their structure as defined by 2D-NMR sp...