The amino acid sequences at the "proteolytic processing regions" of cathepsin Ds have been determined for the enzymes from cows, pigs, and rats in order to deduce the sites of cleavage as well as the function of the proteolytic processing of cathepsin D. For bovine cathepsin D, the "processing region" sequence was determined from a peptide isolated from the single-chain enzyme. The COOH-termina...

The deoxyoligonucleotide d(CGCAATTGCG) has previously been crystallized in four different space groups. The crystals diffract to moderate resolution (2.3-2.9 A). Here, a fifth crystal form that diffracts to higher resolution (1.6 A) is presented which was obtained thanks to the use of Co2+ and cryogenic temperatures. The availability of five different crystal structures allows a thorough analys...

The aim of this paper is to describe a technique for generating three dimensional images of specific microanatomical elements within serial sections. Unlike other three-dimensional reconstruction techniques, this one not only enables the concurrent visualization of multiple structures/tissues (eg: blood vessels, lymphatic tissue, epithelia) but can also reveal spatial topography that can only b...

The authors propose a new realization algorithm for the 2-D FIR Wiener filters. The reduced-order 2-D orthogonal lattice filter structure is used as its principal component as in the 1-D case. A numerical example is included to verify the formulation. Introduction: One-dimensional (1-D) lattice structures have been wiedly used, as a subsystem, to solve FIR Wiener filtering problem. The lattice ...

Analyzing three dimensional protein structures is a very important task in molecular biology. Nowadays, the solution for protein structures often stems from the use of the state-of-the-art technologies such as nuclear magnetic resonance (NMR) spectroscopy techniques or X-Ray crystallography etc. as seen in the increasing number of PDB [34] entries. Protein Data Bank is a database of 3D structur...

Five new lanthanide 1-D coordination polymers are reported which are formed from flexible salen type Schiff-base ligands H(2)L and H(2)L' (H(2)L = N,N(1)-ethylene bis(salicylideneimine); H(2)L' = N,N(1)-bis(3-methoxysalicylidene)ethylene-1,2-diamine). The polymeric structures are formed by bridging neutral H(2)L units in the case of {[Ln(2)L(2)(CF(3)SO(3))(H(2)L)(4)(MeOH)] x CF(3)SO(3)}(n) (Ln ...

In this paper, we consider the problem of the dynamic processing of large amounts of sparse three-dimensional data. It is assumed that computations are performed in a neighborhood defined around each point in order to retrieve local properties. This general kind of processing can be applied to a wide variety of problems. We propose a new, efficient data structure and corresponding algorithms th...

Changes in the function of dopamine D(1)-influenced neuronal pathways may be important to the pathophysiology of several human diseases. We recently developed methods for averaging functional imaging data across nonhuman primate subjects; in this study, we apply this method for the first time to map brain responses to experimental dopamine agonists in vivo. Here we report the use of positron em...