Male-specific transplantation antigen (H-Y)-immune cytotoxic T cells of some individual CBA/H mice exhibit lytic activity on male and female allogeneic targets (e.g., H-2b). Neonatal tolerance to H-2b abrogates the ability of CBA mice to generate secondary H-Y-immune cytotoxic T cells, but such cell activity to third-party alloantigens and to Bebaru and influenza virus is not impaired. The resu...

Lymphocytes derived from animals immunized against alloantigens exhibit in vitro cytotoxicity for target cells carrying the respective isoantigen (1). This cytotoxic activity is mediated by theta-bearing (thymus-derived) lymphocytes (T cells) 1 (2, 3). The accumulated evidence indicates that the cellular immune response to an isoantigen or tumor cell exists concomitantly with isoantibodies secr...

The aim of this study was to develop a tumour vaccine with the ability to induce and expand higher affinity cytotoxic T lymphocytes and stimulate an effective antitumour immune response. The hypothesis tested was that G422 glioblastoma cells modified with B7-1 and interferon (IFN)-gamma genes could serve as a tumour vaccine. It was found that therapeutic subcutaneous immunizations with this tum...

Vaccination with a nucleopeptide (NP 118; amino acids 118 to 132) representing a cytotoxic T-cell epitope of lymphocytic choriomeningitis virus (LCMV) can modulate immunopathology. Immunization with NP 118 protected H-2d mice against intracerebral infection with the LCMV-ARMSTRONG isolate. However, when NP 118-primed H-2d mice were challenged intracerebrally with an intermediate dose (5 x 10(4)...

different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

salvia is one of the largest genera of  lamiaceae family. several species of this genus are perfumed and wealthy in essential oils. some of them are used in industry, pharmacy and aromatherapy. they have shown different biological effects such as antibacterial and antioxidant activity. for the present study, salvia verticillata l. was collected from shahrestanak, mazandaran, iran. hydrodistille...

objective: homalium letestui pellegr (flacourtiaceae) is used in traditional medicine in parts of nigeria for the treatment of malaria, ulcer, and inflammatory diseases and as an aphrodisiac. this investigation was aimed to evaluate the cytotoxic, immunomodulatory, and antileishmanial properties of stem extract and fractions of homalium letestui (h. letestui). materials and methods: cytotoxic a...

background: achillea talagonica (asteraceae) is an endemic herbaceous plant in iran with small yellow flowers and several times pinnately divided leaves in worm shape. the plant was found to be cytotoxic in our previous studies.   materials and methods: a. talagonica was collected in may 2005 from talegan in north of iran during the full flowering stage. dried aerial parts of the plant were red...