نتایج جستجو برای: cytogenetic abnormalities
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BACKGROUND The difference in prognosis of adult and childhood acute lymphoblastic leukemia (ALL) can be attributed largely to variation in cytogenetic abnormalities with age groups. Cytogenetic analysis in acute leukemia is now routinely used to assist patient management, particularly in terms of diagnosis, disease monitoring, prognosis and risk stratification. Knowing about cytogenetic profile...
To investigate cytogenetic evolution after upfront autologous stem cell transplantation for newly diagnosed myeloma we retrospectively analyzed fluorescence in situ hybridization results of 128 patients with paired bone marrow samples from the time of primary diagnosis and at relapse. High-risk cytogenetic abnormalities (deletion 17p and/or gain 1q21) occurred more frequently after relapse (odd...
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic diseases with inefficient hematopoiesis. Diagnosis is based on the persistence of at least one cytopenia for more than 6 months, together with cytological and cytogenetic bone marrow abnormalities, a variety of other diagnosis being discarded. Most patients will die from the consequences of cytopenias. These disea...
OBJECTIVE To study the prevalence of chromosomal abnormalities and FMR1 gene premutation in Chinese women with premature menopause in Hong Kong. DESIGN Retrospective study. SETTING Clinical Genetic Service, Hong Kong. PARTICIPANTS Chinese women with premature menopause referred for cytogenetic study from January 1983 to November 2003. MAIN OUTCOME MEASURES Chromosomal abnormalities, FMR...
background chromosomal abnormality plays an important role in different types of miscarriages. objectives the present study was designed to investigation chromosomal anomalies in three groups of couples with recurrent abortion (ra), spontaneous abortion (sa) and still birth (sb). patients and methods in this retrospective study, the frequency of chromosomal aberrations was investigated among 26...
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