نتایج جستجو برای: cyp51a

تعداد نتایج: 195  

Journal: :Revista iberoamericana de micologia 2013
Emilia Mellado Rafael De La Camara Buenaventura Buendía Juan L Rodriguez-Tudela Manuel Cuenca-Estrella

BACKGROUND An allogeneic hematopoietic cell transplantation (allo-HCT) patient presented with chronic pulmonary aspergillosis associated to pulmonary graft versus host disease (GVHD) and was treated for a long time with several antifungal agents that were administered as prophylaxis, combination therapies, and maintenance treatment. The patient suffered from a breakthrough invasive pulmonary as...

2017
Tiffany S. Norton Qusai Al Abdallah Amy M. Hill Rachel V. Lovingood Jarrod R. Fortwendel

Post-translational prenylation mechanisms, including farnesylation and geranylgeranylation, mediate both subcellular localization and protein-protein interaction in eukaryotes. The prenyltransferase complex is an αβ heterodimer in which the essential α-subunit is common to both the farnesyltransferase and the geranylgeranyltransferase type-I enzymes. The β-subunit is unique to each enzyme. Farn...

Journal: :Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2016
Judith van Paassen Anne Russcher Astrid Wm In 't Veld-van Wingerden Paul E Verweij Eduard J Kuijper

The prevalence of invasive aspergillosis (IA) at the intensive care unit (ICU) is unknown and difficult to assess since IA also develops in patients lacking specific host factors. In the Netherlands, increasing azole-resistance in Aspergillus fumigatus complicates treatment of patients with IA. The aim of this study was to determine the prevalence of IA by azole-resistant A. fumigatus at the IC...

Journal: :Journal of clinical microbiology 2014
Daisuke Hagiwara Hiroki Takahashi Akira Watanabe Azusa Takahashi-Nakaguchi Susumu Kawamoto Katsuhiko Kamei Tohru Gonoi

The emergence of azole-resistant strains of Aspergillus fumigatus during treatment for aspergillosis occurs by a mutation selection process. Understanding how antifungal resistance mechanisms evolve in the host environment during infection is of great clinical importance and biological interest. Here, we used next-generation sequencing (NGS) to identify mutations that arose during infection by ...

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