Vascular smooth muscle cells (VSMCs) are exposed to hormonal and mechanical stress in vivo. Hormonal factors have been shown to affect hypoxia-inducible factor-1alpha (HIF-1alpha). How mechanical stress affects the regulation of HIF-1alpha in VSMCs has not been reported previously, and therefore we sought to investigate the regulation of HIF-1alpha by cyclical mechanical stretch in cultured rat...

The paper presents a family of cycloidal cyclical surfaces, which are created by a movement of a circle alongside the special spatial cycloidal curve, where the circle is located in the curve normal plane and its centre is on this curve. The spatial cycloidal curve can be created by simultaneous revolution of a point about three different axes 3o,2 o and 1o in the space. The form of the cycloid...

I propose a method to estimate cyclical DSGE models using the raw data. The approach links the observables to the model counterparts via a ‡exible speci…cation which does not require that the cyclical component is solely located at business cycle frequencies and allows the noncyclical component to take various time series patterns. Applying standard data transformation induces distortions in st...

Bronchoconstrictor responses are quantitatively different when they are evoked under static conditions and during or after periods of deep inspiration. In vivo, deep inspirations produce bronchodilation and protect the lung from subsequent bronchoconstriction (termed bronchoprotection). These effects may be due in part to dynamic stretch on airways produced by cyclical expansion of airway diame...