Noradrenaline-elicited accumulation of cyclic AMP and effects of an alpha-, beta-adrenoceptor, or adenosine receptor antagonist on the accumulation were examined in slices of different areas of rat cerebral cortex in which ferrous chloride solution was injected unilaterally into the sensorimotor cortex to induce epileptiform activity. The cyclic AMP accumulation was altered regionally in relati...

cyclic GMP during phagocytosis implies a difference in mechanism of action for these nucleotides. Since cyclic GMP is consistently found within the granular cytoplasmic region of the cell, it is likely, as others have suggested (8, 13, 21), that cyclic GMP plays a rol.e in the functional process of secretion. KATHERINE B. PRYZWANSKY Department ofBacteriology and Immunology, University ofNorth C...

Potentiostatic, galvanostatic and cyclic potentiodynamic depositions of polyaniline were studied by cyclic voltammetry and in-situ Raman spectroscopy. Multivariate analysis of the spectroelectrochemical data including evolving factor analysis, multivariate curve resolution and 2Dcorrelation spectroscopy was applied to resolve overlapped bands in Raman spectra and to assign them reliably. Oxidiz...

Fair reachability analysis is generalized to multi-cyclic protocols defined in the communicating finite state machine model as networks of n ≥ 2 processes with a multiple unidirectional ring topology and with arbitrary process structures. As a result, the deadlock detection problem is shown to be decidable for multi-cyclic protocols whose fair reachable global state space is finite. A sufficien...

In developing Dictyostelium discoideum cells, binding of cyclic AMP to the chemotactic receptor has been shown to oscillate. These oscillations represent cycles of activation, adaptation and deadaptation of the cyclic AMP receptor system. We studied the molecular basis of these oscillatory changes in cyclic AMP receptor binding. We developed a rapid method of lysing cells during the course of t...

An impro&d, simplified procedure is described for the isolation of liver cells from rat or chicken. Livers were perfused in sifu and then incubated in a solution of collagenase and hyaluronidase. Greater than 50 % of the liver mass was converted into a suspension of intact parenchymal cells which excluded a vital stain and were undamaged when viewed with the electron microscope. The cells activ...

Addition of 1-3 mM-8-bromo-cyclic AMP to monolayer cultures of H-4 rat hepatoma cells resulted in a rapid but short-lived increase in tyrosine aminotransferase (EC 2.6.1.5) activity. The transient nature of this induction is due to desensitization to 8-bromo-cyclic AMP. Throughout this time course of induction and desensitization, removal of 8-bromo-cyclic AMP resulted in a rapid and significan...

in a large scale cyclic storage system ,as the number of rule parameters and/or number of operating period increase, general purpose gradient-based nlp solvers and/or genetic algorithms may loose their merits in finding optimally feasible solution to the problem. in these cases hybrid ga which decomposes the main problem into two manageable sub-problems with an iterative scheme between ga and l...