We describe a patient with methicillin-resistant Staphylococcus aureus (MRSA) who developed resistance to daptomycin, a new cyclic lipopeptide recently approved for the treatment of infections by gram-positive organisms. Development of resistance to daptomycin during prolonged use may occur with MRSA bacteremia

A patient with well documented cyclic neutropenia (CN) was given chronic lithium therapy as well as a short course of plasmapheresis with therapeutic intention. While on lithium therapy. an increase in the amplitude of the granulocyte oscillations was observed. but recurrent agranulocytotic periods persisted. A 2-wk course of plasmapheresis (total exchange 1 7 liters) resulted in a gradual decr...