Prostaglandin E(2) (PGE(2)), a major product of cyclooxygenase enzymes, is implicated in colorectal carcinogenesis and has been shown to stimulate the growth of human colorectal carcinoma cells. Here, we show that PGE(2) activated the cyclic AMP/protein kinase A pathway, which induced the expression of amphiregulin (AR), an epidermal growth factor family member, through activation of a cyclic A...

A series of pyrazine (pz) complexes containing cis-(NH(3))(2)Pt(II), (tmeda)Pt(II) (tmeda = N,N,N',N'-tetramethylethylenediamine), and trans-(NH(3))(2)Pt(II) entities have been prepared and characterized by X-ray crystallography and/or 1H NMR spectroscopy. In these compounds, the pz ligands act as monodentate (1-3) or bidentate bridging ligands (4-7). Three variants of the latter case are descr...

Clinical trials of beta-adrenergic receptor agonists and cyclic nucleotide phosphodiesterase inhibitors in heart failure have demonstrated a reduction in survival in treated patients despite initial inotropic responses. These findings have led many to infer that activation of the mechanisms through which contractility is increased has deleterious effects on failing myocardium. It should be reme...

Finite affine groups are given by groups of translations and di- lations on finite cyclic groups. For cyclic groups of prime order we develop a time-scale (wavelet) analysis and show that for a large class of non-zero window signals/vectors, the generated full cyclic wavelet system constitutes a frame whose canonical dual is a cyclic wavelet frame.

The light weight of magnesium alloys makes them a promising material in different potential industries, such as aerospace and automobile. In addition, are attractive materials for biomedical applications due to their biocompatibility with the human body. these structural parts require an understanding fatigue behavior because they usually subjected time-varying loading. Furthermore, notches ine...

Structural luteolysis occurs by apoptosis of luteal cells. The present study examined the effects of activators of well-characterized second messengers on Fas and caspase-3 mRNA expression and on P4 production in luteal cells in order to trace the pro- and anti-apoptotic factors in the bovine corpus luteum (CL). Cultured bovine mid luteal cells were treated for 24 h with a cyclic AMP analogue (...

The cyclic nucleotide-gated (CNG) cation channel of rod photoreceptors is a heterotetramer consisting of homologous CNGA1 and CNGB1a subunits. While CNGA1 is indispensable for channel activation, the specific role of CNGB1a in this process has remained elusive. Here, we show that the N-terminal glutamic acid-rich protein (GARP) domain of CNGB1a and soluble GARP2, which corresponds to the proxim...

This can be stated in a more symmetric manner. Let r be any positive integer not equal to 3. Then n acts freely and homologically trivially on Z r i ff n acts freely and homologically trivially on SL In fact, there is a one-to-one correspondence between such actions on U and such actions on S r. (The classification of such actions is discussed in w In addition the actions constructed have the p...

experimental study of the cyclic behavior of unsaturated materials is more complex than that of the saturated materials due to the required equipment, experience and time. furthering investigations in the field of unsaturated materials is necessary to better understand its complexity and sensitivity of unsaturated cyclic parameters to different determinants such as suction path, stress path, lo...