Copper (II) is a biologically active essential ion and it forms the active centers in several metalloenzymes and proteins. Its chelating ability and positive redox potential allow participation in biological transport reactions. The copper atom transforms between the Cu(I) and Cu(II) oxidation states in redox reactions involving copper containing enzymes. This is an essential factor for many of...

background & aim: in order study the effect of thiobacillus, sulphur and organic materials on vegetative growth and essence production in lemon balm (melissa officinalis l.) was conducted in pots in field condition at shahrekord, iran on 2008. experimental: the factors were ten soil treatments inclusive 200 kg/ha sulphur, 400 kg/ha sulphur, 600 kg/ha sulphur, 200 kg/ha sulphur + thiobacill...

Derived from the extensive work in the area of small molecule zinc(II) ion sensors, chelating fragment libraries of quinoline- and benzimidazole-sulfonamides have been prepared and screened against several different zinc(II)-dependent matrix metalloproteinases (MMPs). The fragments show impressive inhibition of these metalloenzymes and preferences for different MMPs based on the nature of the c...

Different models to treat metal-catalyzed enzyme reactions are investigated. The test case chosen is the recently suggested full catalytic cycle of manganese catalase including eight different steps. This cycle contains O—O and O—H activations, as well as electron transfer steps and redox active reactions, and is therefore believed to be representative of many similar systems. Questions concern...

With the goal to study the mechanisms of dinuclear metalloenzymes, new synthetic and computational models for such proteins were prepared and studied. Multidentate ligands based on a central phenolate and with imidazoleand carboxylate-containing donor moieties were synthesized to simulate carboxylate-rich ligand environments. The two ligands that were found to be the most useful, were the symme...

Oxidation reactions are an important part of the synthetic organic chemist's toolkit and continued advancements have, in many cases, resulted in high yields and selectivities. This review aims to give an overview of the current state-of-the-art in oxygenation reactions using both chemical and enzymatic processes, the design principles applied to date and a possible future in the direction of hy...