OBJECTIVE To examine temporal trends in the incidence of epilepsy recorded in UK primary care and to evaluate the impact of recent efforts to improve the specificity of diagnosis in children. DESIGN Birth cohort study using primary care data from The Health Improvement Network, which includes a representative sample of the UK population of approximately 5%. METHODS We identified epilepsy re...

This paper develops omnibus tests for comparing cause-speciic hazard rates and cumulative incidence functions at speciied covariate levels. Conndence bands for the diierence and the ratio of two conditional cumulative incidence functions are also constructed. The omnibus test is formulated in terms of a test process given by a weighted diierence of estimates of cumulative cause-speciic hazard r...

Background: Obesity and overweight are important public health problems which are rapidly growing throughout the world. This study aims to provide 10-year incidence estimates of obesity and overweight in adults along with their risk factors in an Iranian adult population. Methods: This cohort study was conducted within the framework of the Yazd Healthy Heart Project (YHHP) throughout phases fro...

OBJECTIVE In the population-based Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) cohort, we sought to examine whether a decline in the prevalence and incidence of end-stage renal disease (ESRD) was evident with increasing calendar year of type 1 diabetes diagnosis among people followed for 25 years. Factors associated with the hazard of incident ESRD that may mediate a decline we...

BACKGROUND Appropriate statistical analysis is required to measure the impact of early detection and treatment of cancer. The current practice of using cumulative mortality ignores both (1) the delay between early treatment and the time that any averted deaths would have otherwise occurred, and (2) cessation of these delayed benefits some time after screening is discontinued. METHODS We use t...

BACKGROUND The effects of weather on West Nile virus (WNV) mosquito populations in the United States have been widely reported, but few studies assess their overall impact on transmission to humans. OBJECTIVES We investigated meteorologic conditions associated with reported human WNV cases in the United States. METHODS We conducted a case-crossover study to assess 16,298 human WNV cases rep...

OBJECTIVE Little is known about the incidence of secondary neoplasms among survivors of retinoblastoma in Japan. The objective of our study was to analyze the cumulative incidence rate of secondary neoplasms following retinoblastoma and to investigate the risk factors of developing secondary neoplasms. METHODS We conducted a retrospective cohort study of 754 retinoblastoma patients who visite...

PURPOSE To evaluate the 5-year incidence rate of blebitis and bleb-associated endophthalmitis in the United States. METHODS In this retrospective cross-sectional study, we utilized a large commercial health insurance claim-based database during 2007-2011 and identified all patients who had a record of trabeculectomy in 2007. These patients were followed until the end of 2011. During the follo...

BACKGROUND To report our prospective experience on the incidence and pattern of oxaliplatin (OXA)-induced peripheral neuropathy (OXA-IPN) in patients with colorectal cancer (CRC) treated with either FOLFOX-4 or XELoda + OXaliplatin (XELOX). PATIENTS AND METHODS One hundred and fifty patients scheduled to be treated with either FOLFOX or XELOX for CRC were prospectively monitored at baseline a...

Evidence is lacking on whether the duration and timing of low socioeconomic position (SEP) across a person's life course may be associated with incidence of type 2 diabetes mellitus (T2D). The authors' objectives were to investigate associations between cumulative SEP and the incidence of T2D in the Framingham Offspring Study (n = 1,893; 52% women; mean baseline age = 34 years). Pooled logistic...