Cancers, especially of the neural tissue, are often deemed a death sentence. However, neither cellular and molecular mechanisms nor underlying causes fully defined. Despite what is currently known about various types brain tumors, it remains poorly understood how they spread cause collateral damage to other parts brain. This research focuses cerebrospinal fluid (CSF) leakage enzymes from cancer...

Surgical repair of cerebrospinal fluid (CSF) leak requires the production of a seal competent to resist CSF pressure during the period of healing. Direct suturing, packing with muscle and fat grafts, and coverage with mucosal or muscle flaps have been effective in repairing most CSF leaks. Fibrin glue will improve the results of a CSF leak repair by providing better adhesion of the graft and im...

Several biochemical markers in the cerebrospinal fluid (CSF) of 120 patients with serous meningoencephalitis (SM) of viral origin were compared with those of 74 patients with viral or bacterial infections accompanied by neck stiffness but no CSF abnormality (i.e., meningism). CSF adenylate kinase was higher (P less than 0.025) in SM and correlated with lactate concentration (r = 0.37; P less th...

with lumbar disk herniation; however, we do not yet fully understand its pathophysiological mechanism. Besides, the effect of the compression of the bulging disk directly on the nerve roots, biochemical, autoimmune effects, or both, of the nucleus pulposus on the nerve root may play an important role.1-4 As the cerebrospinal fluid (CSF) surrounds the spinal nerve roots, after injury to the root...

provided the original work is properly cited. CC Intrathecal catheters has been placed for the management of a wide range of medical and surgical conditions [1]. As the use of intrathecal catheters increases, surgeons and anesthesiologists must be made aware of possible complications related to their placement, including infection, headache, pneumocephalus, cerebrospinal fluid (CSF) leakage, ne...

Spontaneous intracranial hypotension is a clinical entity characterized by orthostatic headache, low CSF pressure and specific cranial imaging techniques. Headache can be accompanied by the symptoms such as tinnitus, vertigo, diplopia, nausea and vomiting. It is important for the diagnosis to show the level of CSF leakage. Epidural blood patch should be planned for the treatment of patients wit...

Detection of CSF Leakage by Isoelectric Focusing on Polyacrylamide Gel, Direct Immunofixation of Transferrins, and Silver Staining, Freek W.C. Roelandse,* Nico van der Zwart, Jan H. Didden, Jenny van Loon, and John H.M. Souverijn (Dept. of Clin. Chem., Leiden Univ. Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; *author for correspondence: fax 1 31/71/5266753, e-mail roelandse@...

Characterizing the normal distribution of cerebrospinal fluid (CSF) in the spine is crucial for an accurate assessment of CSF leakage and other abnormalities. Magnetic resonance myelography (MRM) is a noninvasive diagnostic method that is commonly used to evaluate the spinal distribution of CSF. Our aim was to evaluate the anatomical distribution of CSF in the spine of healthy individuals, by M...

INTRODUCTION Spontaneous intracranial hypotension is one of the causes of a postural headache in young people. In this study, the diagnosis and treatment results of a case of intracranial hypotension headache due to spinal cerebrospinal fluid leakage were reported. Up to now, there is not absolutely effective treatment for intracranial hypotension headache. CASE DESCRIPTION A 32-year-old woma...

Postdural puncture headache (PDPH) is a debilitating side effect of spinal anesthesia, the result of dural puncture and cerebrospinal fluid (CSF) leakage with an incidence of 3% to 75% in patient populations. Despite numerous in vitro and in viva studies that have identified predictors associated with PDPH, debate continues on the best technique to reduce CSF leak after dural puncture. The purp...