نتایج جستجو برای: csc

تعداد نتایج: 3484  

Journal: :Medicines 2021

The adhesion of cancer cells to vascular endothelium is a critical process in hematogenous metastasis and might be similar the recruitment leukocytes at site inflammation. It mediated by E-selectin its ligands, which most stereospecific glycoconjugate sialyl Lewis x (CD15s), may expressed as an oligosaccharide branch CD44 glycoprotein, well self-contained glycosphingolipid. also known that incr...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2005
Song Gao Keyang Chen Yinzhi Zhao Celeste B Rich Lijun Chen Sandy J Li Paul Toselli Phillip Stone Wande Li

Lysyl oxidase (LO) catalyzes crosslinking of collagen and elastin essential for maintaining the structural integrity of the lung extracellular matrix (ECM). To understand mechanisms of cigarette smoke (CS)-induced emphysema, we investigated effects of cigarette smoke condensate (CSC), the particulate matter of CS, on LO mRNA expression in cultured rat fetal lung fibroblasts (RFL6). Exposure of ...

2013
Kosuke Ueda Sachiko Ogasawara Jun Akiba Masamichi Nakayama Keita Todoroki Keiko Ueda Sakiko Sanada Shigetaka Suekane Masanori Noguchi Kei Matsuoka Hirohisa Yano

Cancer stem cells (CSC) or cancer stem cell-like cells (CSC-LCs) have been identified in many malignant tumors. CSCs are proposed to be related with drug resistance, tumor recurrence, and metastasis and are considered as a new target for cancer treatment; however, there are only a few reports on CSCs or CSC-LCs in renal cell carcinoma (RCC). Different approaches have been reported for CSC ident...

2017
Brendan Ffrench Claudia Gasch Karsten Hokamp Cathy Spillane Gordon Blackshields Thamir Mahmoud Mahgoub Mark Bates Louise Kehoe Aoibhinn Mooney Ronan Doyle Brendan Doyle Dearbhaile O'Donnell Noreen Gleeson Bryan T Hennessy Britta Stordal Ciaran O'Riain Helen Lambkin Sharon O'Toole John J O'Leary Michael F Gallagher

It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cell hierarchies. Here we aimed to elucidate the relationship between CSC hierarchies and chemoresistance in an ovarian cancer model. Using a single c...

2014
Heinz-Josef Lenz Michael Kahn

Throughout our life, long-lived somatic stem cells (SSC) regenerate adult tissues both during homeostatic processes and repair after injury. The role of aberrant regulation of SSC has also recently gained prominence in the field of cancer research. Following malignant transformation, so termed cancer stem cells (CSC), endowed with the same properties as SSC (i.e. the ability to both self-renew ...

Journal: :American journal of physiology. Cell physiology 2016
Pithi Chanvorachote Sudjit Luanpitpong

Evidence has accumulated in support of the critical impact of cancer stem cells (CSCs) behind the chemotherapeutic failure, cancer metastasis, and subsequent disease recurrence and relapse, but knowledge of how CSCs are regulated is still limited. Redox status of the cells has been shown to dramatically influence cell signaling and CSC-like aggressive behaviors. Here, we investigated how subtox...

Journal: :Cancer research 2013
Hannah Harrison Lynsey Rogerson Hannah J Gregson Keith R Brennan Robert B Clarke Göran Landberg

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and current therapeutic strategies aim to target the hypoxic response. One way in which this is done is by blocking hypoxia-induced angiogenesis. Antiangiogenic therapies show some therapeutic potential with increased disease-free survival, but these initial promising results are short lived and followed by tumor...

2014
Shumei Song Jaffer A. Ajani Soichiro Honjo Dipen M. Maru Qiongrong Chen Ailing W. Scott Todd R. Heallen Lianchun Xiao Wayne L. Hofstetter Brian Weston Jeffrey H. Lee Roopma Wadhwa Kazuki Sudo John R. Stroehlein James F. Martin Mien-Chie Hung Randy L. Johnson

Cancer stem cells (CSC) are purported to initiate andmaintain tumor growth. Deregulation of normal stem cell signaling may lead to the generation of CSCs; however, the molecular determinants of this process remain poorly understood. Here we show that the transcriptional coactivator YAP1 is a major determinant of CSC properties in nontransformed cells and in esophageal cancer cells by direct upr...

2012
Urszula Gajdzik-Gajdecka Mariola Dorecka Ewa Nita Anna Michalska Joanna Miniewicz-Kurkowska Wanda Romaniuk

BACKGROUND Central serous chorioretinopathy (CSC) is a condition that originates from alterations of the choroidal circulation. The aim of this paper was to evaluate the use of indocyanine green angiography (ICGA) in patients with chronic CSC. MATERIAL/METHODS The analysis included 17 patients (34 eyes) with chronic CSC in at least 1 eye. The eye examination included: distance and near visual...

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