Hepatic cryosurgery is a novel procedure for patients with metastatic liver disease. To date, no reviews of the infectious complications of this procedure have been published. One hundred and fifty patients underwent 158 hepatic cryosurgical procedures at Allegheny General Hospital (Pittsburgh) from November 1987 through July 1995. Gastrointestinal malignancies accounted for 93% of the underlyi...

Abstract Focal therapies, including cryosurgery, thermal ablation, and irreversible electroporation (IRE) are widely used in the treatment of cancer other diseases, aimed at exposing cells to extreme physical conditions leading cell death. ablation outcomes extensively studied small animal preclinical models, such as mice; however, robust engineering characterization these treatments is largely...

Cryotherapy (ice application) and deep cryosurgery are commonly employed for neurological, surgical, and physical therapy. Prolonged and repetitive cryotherapy can result in permanent damage to myelinated nerves which are susceptible to myelin coagulation, axonal destruction, and focal somesthetic nerve dysfunction. The stimulation of microscopic perivascular unmyelinated C-thermoreceptor nerve...

The bioheat transfer simulation is undoubtedly the foundation for developing computerized tools for cryosurgery planning and analysis. While a large variety of techniques for bioheat transfer simulations are available in the literature of the past several decades, it is only their integration with clinical criteria and constraints which can make computerized planning a practical reality. This b...

At our institution giant cell tumors arising in all locations are treated with curettage, cryosurgery, and cementation to avoid resection or amputation, increase local tumor control over curettage alone, and avoid the morbidity associated with immobilization. We report the oncologic and functional results of 3 patients with giant cell tumors arising from the tubular bones of the hand who were t...

The tissue injury and the organization of collagen during cryosurgery are poorly characterized because of the lack of appropriate methodologies. In this study, we use multimodal multiphoton microscopy to assess the change of extracellular matrix after cryotreatment of skin. The cellular matrix transformations and the intercellular interactions during the wound healing process after cryolesion f...

A retrospective study in children with simple or unicameral bone cysts treated with curettage, cryosurgery, and bone grafting was conducted. The purpose of this study was to evaluate local tumor control and bony healing after this method of treatment. Five (12%) of 42 treated patients had a local recurrence with a mean clinical follow-up of 24.5 months. Surgical complications consisted of two s...