BACKGROUND The main treatments for cancers are still chemotherapy and radiotherapy for intermediate-stage cancer and terminal cancer. However, the therapeutic methods often result in a decreased neutrophilic granulocyte count and other side effects. In this study, in order to improve the neutrophilic granulocyte levels in the blood after radiotherapy and chemotherapy, we developed a sustained-r...

Myoglobin and haemoglobin may frequently be found together in the urine of patients who have suffered from crush injuries. The separation of these two haemo-proteins by differential solubility in salt solutions and their spectroscopic characterization are technically difficult. With this in mind, it appeared worth while to test whether the considerable difference in molecular size of the protei...

The purpose of this research was to formulate and systematically evaluate in vitro performances of chitosan microspheres containing Mitomycin-C. Chitosan microspheres containing Mitomycin-C were prepared by simple emulsification phase separation technique using glutaraldehyde as a cross-linking agent. Results of preliminary trials indicate that volume of cross-linking agent, time for cross-link...

Collagen, the main protein of body, is extracted in different forms and used as reservoir for drug delivery. The aim this work was to obtain adrug delivery systems based on collagen-dextran matrices cross-linked with glutaraldehyde support flufenamic acid and/or microcapsules drug. encapsulated polymeric consisting gelatin, alginate sodium carboxymethyl cellulose. morphology determined by water...

This study was conducted for evaluation of the ability to maintain efficacy and biocompatibility of cross-linked dextran in hydroxypropyl methylcellulose (DiHM) and cross-linked dextran mixed with PMMA in hydroxypropyl methylcellulose (PDiHM), compared with hyaluronic acid (HA) filler. Saline and HA solution was administered in the negative and positive control groups, and DiHM and PDiHM were a...

Hydrogels play an important role in macroscale delivery systems by enabling the transport of cells and molecules. Here we present a facile and benign method to prepare a dextran-based hydrogel (Dex-sHSA) using human serum albumin (HSA) as a simultaneous drug carrier and covalent cross-linker. Drug binding affinity of the albumin protein was conserved in the thiolation step using 2-iminothiolane...

Dextran is a bacterial polysaccharide consisting essentially of -1,6 linked glucopyranoside residues with a small percentage of -1,3 linked residues. In the first part of the chapter we discuss methodologies to chemically modify dextran. Taking into account our previous work, we focus our attention in the oxidation of dextran and in the transesterification of dextran by enzymatic means. We disc...

The purpose of this research was to formulate and systematically evaluate in vitro performances of chitosan microspheres containing Mitomycin-C. Chitosan microspheres containing Mitomycin-C were prepared by simple emulsification phase separation technique using glutaraldehyde as a cross-linking agent. Results of preliminary trials indicate that volume of cross-linking agent, time for cross-link...

Invasive fungal infections can be devastating, particularly in immunocompromised patients, and difficult to treat with systemic drugs. Furthermore, systemic administration of those medications can have severe side effects. We have developed an injectable local antifungal treatment for direct administration into existing or potential sites of fungal infection. Amphotericin B (AmB), a hydrophobic...