In the present investigation, a novel multifunctional co-processed superdisintegrants consisting of crospovidone and Kyron T-314 were fabricated by solvent evaporation method to develop melt-in-mouth tablets of metoclopramide hydrochloride with a view to enhance patient compliance by direct compression method. The simple physical blends and co-processed mixture of superdisintegrants were charac...

Dr E J VELLA (Pathology Laboratory, Lakin Road, Warwick CV34 5BJ) and Dr C W EDWARDS (Departme9e of Pathology, East Birmingham Hospital, Birmingham B9 5ST) write: A 31 year old female drug misuser presented with pain in her right leg. She told the casualty doctor that a few hours previously she had crushed a few 10 mg tablets of temazepam, dissolved them in water, and injected the solution intr...

Dr E J VELLA (Pathology Laboratory, Lakin Road, Warwick CV34 5BJ) and Dr C W EDWARDS (Departme9e of Pathology, East Birmingham Hospital, Birmingham B9 5ST) write: A 31 year old female drug misuser presented with pain in her right leg. She told the casualty doctor that a few hours previously she had crushed a few 10 mg tablets of temazepam, dissolved them in water, and injected the solution intr...

In this research work, different blends of superdisintegrants with different ratio in fixed concentration were taken and placebo tablets were formulated and evaluated with a view to optimize a formula and concentration blends of superdisintegrants for Fast Disintegrating Tablets (FDT). In this research work three superdisintegrants, viz. Crosscarmellose, Crospovidone and Sodium Starch Glycolate...

Naproxen sodium is an analgesic NSAID (non steroidal anti inflammatory drug) used for the treatment of pain, inflammation, fever and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, juvenile arthritis, gout, migraine and dysmenorrhea. However, the gastric discomfort caused by drug results in poor patient compliance associated with its conventional dosage forms. Hence...

Many patients especially children and elderly have difficulty in swallowing tablets and capsules and consequently unable to take medicine as prescribed. Almost 50% of the population is affected by such problem, resulting in the high incidence of non compliance and ineffective therapy. Most pharmaceutical forms for oral administration are formulated for direct ingestion, or for chewing, or for p...

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disint...

The spread of sexually transmitted infections caused by herpes simplex virus type 2 (HSV-2) has continued unabated. At least 20% of the United States population has been infected with HSV-2 and there is a high probability of further virus transmission by asymptomatic carriers. Given the absence of effective vaccines, this indicates the need to develop prophylactic measures such as topical micro...