1. Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, RJ, Brazil. 2. Hospital Casa de Portugal / 3D Diagnóstico por Imagem, Rio de Janeiro, RJ, Brazil. 3. Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. Mailing Address: Dr. Bruno Niemeyer de Freitas Ribeiro. Instituto Estadual do Cérebro Paulo Niemeyer – Serviço de Radiologia. Rua do Rezende, 156, Centro. R...

Sporadic: about 85% of case. [4] It is rare at around one case per million population per year. It is found throughout the world, and is thought to be due to a spontaneous mutation of the prion protein. It is not transmitted. Hereditary: a little under 15% of cases. This variant occurs in family clusters with a dominant pattern of inheritance. [4] Iatrogenic CJD: may be transmitted by instrumen...

The laboratory transmission to animals of an apparently degenerative disease of the nervous system, Creutzfeldt-Jakob disease (CJD), is now well established. Important questions arising from this observation are the possibility of natural transmission or infectivity and the existence of other similarly transmissible diseases. Epidemiological studies have revealed some possible clusters of CJD a...

Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadaver-sourced growth hormone during childhood are still being seen in the UK 30 years after cessation of this treatment. Of the 77 patients who have developed iatrogenic CreutzfeldtJakob disease, 56 have been genotyped. There has been a marked change in genotype profile at polymorphic codon 129 of the prion protein ge...

eases are fatal neurodegenerative disorders that include Creutzfeldt–Jakob disease and Gerstmann–Sträussler– Scheincker syndrome in humans, and scrapie, bovine spongiform encephalopathy and chronic wasting disease in animals. These disorders are characterized by accumulation in the brain of an abnormal isoform of prion protein (PrP), which includes a high beta-sheet content and is resistant to ...

BACKGROUND Prion diseases are untreatable, progressive, and fatal brain disorders that occur worldwide, and the annual incidence rate is approximately 1 case per 1 million people. The duration of these diseases in Japan is unclear. METHODS Based on data from 1 April 1999 through 4 September 2008 provided by the Japanese Creutzfeldt-Jakob disease (CJD) surveillance program, we analyzed disease...

Creutzfeldt-Jakob Disease (CJD) is a rare, incurable, fatal degenerative disease of the central nervous system. The majority of cases occur between the ages of 50 and 75 years, although patients as young as 10 years and as old as 80 years have been reported. The disease is not geographically limited and has been reported from over 50 countries around the world. CJD affects both males and female...

no. EU056810) and 1986 (accession nos. HM234642 and GU131843) epidemics in Burkina Faso. Strains of DENV-2 from the 2005 epidemic in Ghana (accession no. EU005258) shared 95% identity with that of the patient reported here. Phylogenetic analysis indicated that the dengue virus genome sequence in this case is highly homologous with recent strains in Africa, especially from the 2016, 1986, and 19...

Sporadic: about 85% of case. [4] It is rare at around one case per million population per year. It is found throughout the world, and is thought to be due to a spontaneous mutation of the prion protein. It is not transmitted. Hereditary: a little under 15% of cases. This variant occurs in family clusters with a dominant pattern of inheritance. [4] Iatrogenic CJD: may be transmitted by instrumen...