background and objective: egfr and her-2 are two members of erbb/her family of type i transmembrane growth factor receptors. cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. the aim of this study was to determine the level of expression of egfr, her-2 and cox2 in colorectd cancer. mater...

objective: oxidative stress damages cells and brings about the pathogenesis of ischemia/reperfusion injury. this study was carried out to investigate the preconditioning and cardio protective potential effects of crocin and vitamin e by the enos and inos express gene in ischemia/reperfusion in rats. material & methods: male rats were divided into seven groups, namely: sham, control group and ex...

objective: bone morphogenetic protein-7 (bmp-7) is a multifunctional growth factor predominantly recognized for its osteoinductive properties. due to the high cost of this protein, the availability of bmp-7 for treatment is limited. the heterologous production of recombinant hbmp-7 has been performed in a number of expression systems. in this study a novel form of bmp-7 was expressed in eukaryo...

Interferon-gamma (IFN-gamma) inhibits proliferation of vascular smooth muscle cells (VSMCs) in culture and reduces arterial restenosis post-balloon angioplasty. The identification and characterization of IFN-gamma-specific transcripts in VSMCs are an important approach to discern the molecular mechanisms underlying vascular proliferative disease. In this report, we describe IRT-1, a novel mRNA ...

Background: Bradford protein assay is popular due to its ease of performance and relative sensitivity. Many researchers and laboratories in Iran use standard assay of Bradford by cuvette. No commercial kit was available for Bradford microplate assay in Iran. Meanwhile, imported Bradford commercial kits are very expensive and have a long delivery time in Iran. Till now no study or document on Br...

in order to evaluate the efficiency of inoculation of chickpea seeds with mesorhizobium and application of nitrogen and zinc on yield and yield components of rainfed chickpea an experiment was carried out in research station of shirvan-chardavel, ilam. the experiment was conducted in randomized complete block design (rcbd) with six treatments including mesorhizobium inoculation, nitrogen (40 kg...

background and objective: histological grading has prognostic and therapeutic implications in meningioma. however, histological criteria are sometimes not fulfilled to predict the biological behavior of meningiomas. p63 gene is a novel p53 family member, known as tumor suppressor factor, with multiple isoforms and shows high expression in many normal and neoplastic human tissues. in this study,...

a study was performed to study the effect of drought stress on protein changes of five wheat genotypes. wheat genotypes were planted in early november, growing season of 2008-2009. the experiment was carried out in a factotial design with three replications. two drought stress levels (irrigated and non irrigated) and five genotype of wheat (f103-l-1-12//pony/opata, f1.158/fdl//blo/3/sh14414/cro...

background and objectives evaluation of protein quality in food is of great importance due to the biological and economical impacts of food proteins. this study has been conducted with the aim of comparing the protein quality of homemade food (mixture of macaroni and soy bean) with commercial baby food (cerelac wheat) using casein as the refference point.   methods this study was conducted on 6...

We have previously characterized transcription factor LZIP to be a growth suppressor targeted by hepatitis C virus oncoprotein. In search of proteins closely related to LZIP, we have identified a liver-enriched transcription factor CREB-H. LZIP and CREB-H represent a new subfamily of bZIP factors. CREB-H activates transcription by binding to cAMP responsive element, box B, and ATF6-binding elem...