Background: Diabetic nephropathy is a common complication of diabetes mellitus type2. The neutrophil gelatinase Associated lippocallin (NGAL) is an ubiquitous protein consist of 178 amino acid. NGAL can be identified in plasma and urine starting 24 hours after a kidney injury resulting changes in glomerular filtration and tubular reabsorption and with increased secretion in tubular epithelial c...

A 80-year-old male presented with anaemia (Hb = 10.2 g/L) in a context of renal insufficiency (creatinin 160 Ìmol/L, no aminoaciduria). Electrophoresis of serum proteins revealed a monoclonal immunoglobulin IgGκ peak (15.8 g/L). Bone marrow aspirate showed 4 % plasma cells containing numerous azurophilic spindle-shaped inclusions mimicking bundles of Auer-rods (Figures 1 a & b). Due to spreadin...

BACKGROUND In this study (the first of two related papers), we report whether the relationship between the demographic and anthropometric variables (DA, i.e. age, gender, height and weight) employed in current creatinin (Cr)-based glomerular filtration rate (GFR) estimation equations and actual GFR is mediated by muscle mass. METHODS We studied 77 patients (mean age +/- SD, 65.1 +/- 11.9 year...

We investigated whether eyedrop vaccination using modified outer membrane vesicles (mOMVs) is effective for protecting against hemolytic uremic syndrome (HUS) caused by enterohemorrhagic E. coli (EHEC) O157:H7 infection. Modified OMVs and waaJ-mOMVs were prepared from cultures of MsbB- and Shiga toxin A subunit (STxA)-deficient EHEC O157:H7 bacteria with or without an additional waaJ mutation. ...

PURPOSE OF THE STUDY to determine the efficacy, adverse effects and safety of a new Iranian generic product of deferasirox (Osveral®) in Iranian transfusion dependent major thalassemic (TD-MT) patients. METHODS In 9 main thalassemia treatment centers, all of TD-MT patients (aged ≥2 yrs) with serum ferritin (SF) levels≥1000 ng/ml, or >100 ml/kg of RBC transfusion,who could not tolerate parenta...

Persistent hyperinsulinemic hypoglycemic in infant is risk factor for impairment during brain development process. Early diagnosis and treatment will result in better outcome. The aim is to report a case of persistent hyperinsulinemic hypoglycaemic infant. Methode is case report. A, 2 days old term infant, was referred due to hypoglicemia. He got generalized seizure and recurrent hypoglicemia. ...

Hospital General Universitario There were no significant differences between patient groups comparing other clinical characteristics, including age, advanced lytic Valencia, Spain M. Linares bone lesions, creatinin levels, and type of treatment. Loss of CD56 Servicio de Hematologia antigen, which was postulated to contribute to the leukemic expresHospital Comarcal de Vinaroz sion in MM, was als...

RATIONALE Chronic obstructive pulmonary disease (COPD) is a common, complex multisystem disease in the elderly with multiple comorbidities that significantly impact morbidity and mortality. Although cerebral small-vessel disease is an important cause of cognitive decline and age-related disability, it is a poorly investigated potential systemic manifestation of patients with COPD. OBJECTIVES ...

Two experiments were performed to screen bacilli isolated from quails for their aflatoxin removal potential and to assess the efficiency of their amelioration of experimental aflatoxicosis. Nonhemolytic bacilli were selected for in vitro aflatoxin B1 (AFB1) removal and conventional probiotic tests. The isolate with the highest scores was selected for assessment in field experiments and was iden...

BACKGROUND In order to detect nephropathy, measurement of total (24 hrs) urinary albumin or albumin/creatinin ratio in random urine samples is being recommended. But methods of albumin measurement are not available in all laboratories and also cost about 6 times more than that of urinary total protein measurement. OBJECTIVES This Study was performed to determine appropriate cut off point in 2...