An enantioselective Friedel-Crafts alkylation with alpha,beta-unsaturated 2-acyl imidazoles and electron-rich aromatic nucleophiles catalyzed by bis(oxazolinyl)pyridine-scandium(III) triflate complexes has been accomplished. These alpha,beta-unsaturated 2-acyl imidazoles are effective electrophiles for the Friedel-Crafts reaction. The resulting adduct 2-acyl imidazole is easily converted to ami...

The Salmonellae PhoP-PhoQ virulence regulators induce resistance to host cationic antimicrobial peptides (CAMP) after infection of vertebrate tissues, and Mg2+ or Ca2+ limitation. The PhoP-PhoQ activated gene, pagP, was identified as important to inducible CAMP resistance and increased acylation of lipid A, the major component of the outer leaflet of the outer membrane. pagP mutants demonstrate...

13 The aim of this work was to study the differential behavior shown by Candida antarctica 14 lipase B during the O-acylation and N-acylation of monofunctional alcohols and 15 monofunctional amines. To achieve this, 2-butanol and sec-butylamine were used as model 16 molecules. Yields, kinetics and enantioselectivity were studied for both reactions. Although a 17 steady-state ordered ternary com...

Lipid modification on the cysteine residues of proteins, known as S-palmitoylation or S-acylation, regulates the subcellular localization and the function of proteins. S-acylation is catalysed by a group of protein acyltransferases (PATs) with a conserved Asp-His-His-Cys (DHHC) motif. The molecular function of S-acylation has been studied in details in yeast and mammalian cells, but its role in...

Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-step reaction pathway and the single-step acylation process is rate-determining....

Trifluoromethanesulfonic acid (TfOH) is one of the superior catalysts for acylation. The catalytic activity of TfOH in Cand/or O-acylation has broadened the use of various substrates under mild and neat or forced conditions. In this review, the salient catalytic features of TfOH are summarized, and the unique controllability of its catalytic activity in the tendency of C-acylation and/or O-acyl...

The amide containing structure is found chemistry and related science. As a consequence, methods for the N-acylation of amines occupies large place in organic chemistry. In this study, Zinc triflate acylation between aniline derivatives furan-2-carbonyl chloride was investigated under mild conditions. Also, different types amides obtained very good yields at room temperature purity after simple...

A facile and efficient protocol for palladium-catalyzed ortho-acylation of 2-aryl pyridines was developed. Note that this acylation utilized arylmethyl amines as new, cheap and readily available acylation reagents and exhibited high regioselectivity for 2-aryl pyridines bearing a meta-substituent in the aryl ring moiety.

Based on the perspective of academic application and cultural dissemination, this study intends to explore the aesthetic value of Taiwan modern crafts. Through an approach of style analysis, this study examines the works selected from Taiwan Crafts Competition Award and Modern Crafts Yii Project. Both qualitative and quantitative methods are employed to explore the artistic essence and cultural...

Acylation reaction of a variety of cyclic ketones via acylation of the corresponding enamines is welldefined in the literature. Enamine acylation of carbonyl compounds is a significant synthetic method because of its mildness and the ease of preparing various β-diketones [1-4]. Acylation reactions are performed by means of converting enamines to the enaminoketones and subsequent hydrolysis of t...