Calorie restriction (CR) and rapamycin (RP) extend lifespan and improve health across model organisms. Both treatments inhibit mammalian target of rapamycin (mTOR) signaling, a conserved longevity pathway and a key regulator of protein homeostasis, yet their effects on proteome homeostasis are relatively unknown. To comprehensively study the effects of aging, CR, and RP on protein homeostasis, ...

PURPOSE We sought to reexpress the 4-variable Modification of Diet in Renal Disease (MDRD) Study equation for estimation of glomerular filtration rate (GFR) using serum creatinine (S(cr)) standardized to reference methods. METHODS Serum specimens included creatinine reference materials prepared by the College of American Pathologists (CAP), traceable to primary reference material at the NIST,...

MEMS gas sensor is one of the development directions of the sensor, and it must work at a certain temperature, so micro heater is an important part of MEMS gas sensor. In this paper, aiming at the high cost and complex process of Pt film heater, we developed the research of Fe/Cr/Al and Ni/Cr cheap metals replacing Pt metal. With Fe/Cr/Al and Ni/Cr metal as the targets respectively, Fe/Cr/Al an...

Interferons are not curative in hairy cell leukemia (HCL), and retreatment is necessary in most patients whose therapy is stopped. In an attempt to maintain or improve responses, we administered recombinant interferon-da (rlFN-da) continuously to patients with HCL who initially responded to this therapy. Of 53 evaluable patients enrolled in this study, 32 have received rlFN-da continuously for ...

Metallic Cr and multilayer CrN/Cr coatings with a thickness of 2.5 µm were deposited onto E110 alloy by magnetron sputtering. Oxidation tests in air performed at 1100 °C for 10–40 min. The gravimetric measurements showed better protective properties comparison metallic coating. Multilayer coating prevented fast Cr–Zr inter-diffusion the formation ZrN layer beneath appearance is caused interacti...

Local cosine/sine basis is a localized version of co-sine/sine basis with a smooth window function. It has orthogonality and good time and frequency localization properties. Adaptive local cosine/sine basis is a best-basis based on a cost-functional obtained from an overabundant library of cosine/sine packets. In this paper, we apply the 2-D semi-adaptive (time-adaptive or space-adaptive) local...

Reduced N-acetyl-aspartate (NAA) levels have been reported in the prefrontal cortex (PFC) in patients with schizophrenia using proton magnetic resonance spectroscopy. However, it is unclear whether this NAA reduction predates the illness onset and is reported in subjects at-risk for developing schizophrenia (HRS). The aim of this study was to assess NAA levels in the PFC in HRS. We hypothesized...

PURPOSE Adult T-cell leukemia (ATL) is usually CD25(+) and rapidly fatal. Anti-CD25 recombinant immunotoxin LMB-2 had phase I activity limited by immunogenicity and rapid growth. To prevent antidrug antibodies and leukemic progression between cycles, a phase II trial was performed with LMB-2 after cyclophosphamide and fludarabine. EXPERIMENTAL DESIGN ATL patients received cyclophosphamide and...

It is of considerable importance to be able to distinguish metallic species because their toxicity depends on their chemical form. Therefore, the analysis of environmental samples can be enhanced by the combination of high-performance thin-layer chromatography (HPTLC) with laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS). In this study, Cr (3+) and Cr (6+) were separated o...

The effect of withaferin A, a plant withanolide, alone or in combination with acute and fractionated radiotherapy and/or hyperthermia, was tested on two mouse tumors, B16F1 melanoma and fibrosarcoma, grown in C57BL and Swiss albino mice, respectively. Tumors were exposed locally to 30 or 50 Gy gamma radiation as acute dose, or 5 fractions of 10 Gy. Withaferin A, 40 mg/kg, was injected intraperi...