Illumination of 3 day old etiolated radish seedlings with continuous white light results in a progressive accumulation of chlorophyll a and b. Both pigments are bound in a different way to the thylakoid chlorophyll-proteins, which appear parallel to the formation of chlorophylls. By applying the SDS-PAGE method to SDS-digested chloroplasts, it was possible to show that the chloroplasts of radis...

BACKGROUND Small cell lung cancer (SCLC) is a common lung cancer which presents with extensive stage disease at time of diagnosis in two-thirds of patients. For treatment of advanced disease, traditional platinum doublet chemotherapy induces response rates up to 80% but with few durable responses. CPI-613 is a novel anti-cancer agent that selectively inhibits the altered form of mitochondrial e...

QoS-aware replica placement decides how many replicas are needed and where to deploy them to meet every request from individual clients. In this paper, a novel three-phase algorithm, namely CPI, is proposed. By dividing candidate nodes into proper medium-scale partitions, CPI is capable to handle with large-scale QoS-aware replica placement problem. Pharos-based clustering algorithm obtains ide...

On October 6, 1979, the Federal Open Market Committee of the Federal Reserve System embarked on an aggressive policy to lower the inflation rate, which then stood near 12 percent. That effort succeeded: By the mid-1980s, the rate of change in the Consumer Price Index (CPI) was reduced to less than 4 percent on a three-year moving-average basis, as shown in figure 1. The commonly reported measur...

PKCα AND CPI-17 EXPRESSION AND SPATIAL-TEMPORAL DISTRIBUTION WITH ACTIVATION IN PIG STOMACH ANTRUM AND FUNDUS Yu Zhang, B.S. Marquette University, 2010 Smooth muscle contraction is a complicated process coordinated by contractile, regulatory and cytoskeletal proteins. The force generation depends on the phosphorylation of Myosin Regulatory Light Chain (MLC20). Myosin Light Chain Kinase (MLCK) a...

Traditional chemotherapeutic drugs are often restricted by severe side effects and lack of tumor specificity. Peptide prodrugs cleavable by peptidases present in the tumor environment have been explored to improve the therapeutic index of cytotoxic drugs. One such prodrug of doxorubicin (Dox), CPI-0004Na [N-succinyl-beta-alanyl-L-leucyl-L-alanyl-L-leucyl-Dox (sALAL-Dox)] has been shown to have ...

The present research developed a new, multi-step approach for hierarchically assessing the Big Five personality domains from a large and diverse pool of existing questionnaire items: those of the California Psychological Inventory (CPI). First, the Abridged Big Five Circumplex (AB5C) structural model was used to organize the CPI item pool in Big Five factor space. Using the 10 resulting CPI-AB5...

Upregulation of the H3K4me3 demethylase JARID1B is linked to acquisition of aggressive, stem cell-like features by many cancer types. However, the utility of emerging JARID1 family inhibitors remains uncertain, in part because JARID1B's functions in normal development and malignancy are diverse and highly context-specific. In this study, responses of oral squamous cell carcinomas (OSCCs) to cat...

Airway hyper-responsiveness (AHR) associated with heightened airway resistance and inflammation is a characteristic feature of asthma. It has been demonstrated that contractile responsiveness and Ca(2+) sensitization to acetylcholine (ACh) in repeated antigen challenge-induced airway hyper-responsive bronchial preparation were significantly increased. The CPI-17 (PKC-potentiated inhibitory prot...

Differential evolution (DE) is a simple and powerful evolutionary algorithm, which has been successfully used in various scientific and engineering fields. Generally, the base and difference vectors of the mutation operator in most of DE are randomly selected from the current population. Additionally, the population information is not fully exploited in the design of DE. In order to alleviate t...