OBJECTIVE Patients with systemic lupus erythematosus are genetically predisposed to enhanced production of the type-I interferon IFN-α and are also at elevated risk of developing atherosclerosis compared with healthy subjects. We aimed to test whether genetic predisposition to increased type-I IFN production affects risk of coronary artery disease. APPROACH AND RESULTS Using a list of 11 sing...

CO2-Plume Geothermal (CPG) power plants can use geologically stored CO2 to generate electricity. In this study, a Flexible Plume (CPG-F) facility is introduced, which provide dispatchable power, energy storage, or both and storage simultaneously—providing baseload with for demand response. It found that CPG-F deliver more than CPG plant, but less daily production. For example, the produces 7.2 ...

in induction of systemic and mucosal immunity, particulate antigens are more effective than soluble antigens possibly because they are more efficiently endocytosed by mucosal-associated lymphoid tissue (malt) m cells. in this study, we determined the systemic and mucosal immune responses in rabbits following intranasal immunization of tetanus toxoid tt and cpg-odn encapsulated within plga nanos...

Methylation of CpG islands associated with genes can affect the expression of the proximal gene, and methylation of non-associated CpG islands correlates to genomic instability. This epigenetic modification has been shown to be important in many pathologies, from development and disease to cancer. We report the development of a novel high-resolution microarray that detects the methylation statu...

DNAs from bacteria and variety of nonvertebrate organisms, including nematodes, mollusks, yeasts, and insects, cause polyclonal activation of murine B lymphocytes. Similar studies have not been reported for bovine B cells, and to date no studies have reported mitogenic properties of protozoal DNA for any species. However, we and others have observed that protozoal parasite antigens can induce t...