Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...

background: lymphomas are a group of malignancies affecting b, t and nk cells. cox-2 enzyme is one of the known inflammatory factors which increase in the inflammation process. increase in cox-2 expression inhibits apoptosis and increases tumor cells invasion and angiogenesis. increase in the cox-2 gene expression is seen in a group of cancers .specific cox-2 inhibition also can be beneficial i...

Although unregulated activation of the Ras/Raf/mitogen-activated protein kinase kinase/Erk signaling pathway is believed to be a central mechanism by which many cell types undergo oncogenic transformation, recent studies indicate that activation of Raf kinase by oncogenic Ras is not sufficient to cause tumorigenic transformation in intestinal epithelial cells. Thus, identification of signaling ...

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a naturally occurring compound shown to inhibit 7,12–dimethylbenz[a]anthracene-induced preneoplastic lesions in mouse mammary organ culture and 12O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumors. It has been postulated that resveratrol may inhibit tumorigenesis in mouse skin through interference with reactive oxidant pathways, and po...

This paper presents two score tests to determine a value for the Box–Cox transformation parameter. The test based on expected information performs better in small samples and is computationally simpler than the one based on observed information; therefore, the former is recommended.  2002 Elsevier Science B.V. All rights reserved.

AMS 2000 subject classifications: 62N02 62G20 Keywords: Kaplan–Meier estimator Martingale Proportional hazards model Proportional odds model Right censoring U-statistic a b s t r a c t Recent advances in the transformation model have made it possible to use this model for analyzing a variety of censored survival data. For inference on the regression parameters, there are semiparametric procedur...

background : gastric cancer is the one of the most prevalent reason of cancer-related death in the world. survival of patients after surgery involves identifying risk factors. there are various models to detect the effect of risk factors on patients’ survival. the present study aims at evaluating these models. methods : data from 330 gastric cancer patients diagnosed at the iran cancer institut...

survival analysis is a set of methods used for analysis of the data which exist until the occurrence of an event. this study aimed to compare the results of the use of the semi-parametric cox model with parametric models to determine the factors influencing the length of stay of patients in the inpatient units of women hospital in tehran, iran. in this historical cohort study all 3421 charts of...

UNLABELLED Oral lichen planus and lichenoid reactions are autoimmune type inflammatory conditions of the oral mucosa with similar clinical and histological characteristics. Recent data suggest that oral lichenoid reactions (OLR) present a greater percentage of malignant transformation than oral lichen planus (OLP). OBJECTIVE To compare the expression of bcl-2 and COX-2 in OLP and OLR. METHO...