Award Number: W81XWH-07-1-0448 TITLE: Structural and Mechanistic Analyses of TSC1/2 and Rheb 1/2Mediated Regulation of the mTORC Pathway PRINCIPAL INVESTIGATOR: PI: David M. Sabatini, M.D./Ph.D. CONTRACTING ORGANIZATION: Whitehead Institute for Biomedical Research Cambridge, MA 02142-1493 REPORT DATE: July 2009 TYPE OF REPORT: Annual Report PREPARED FOR: U.S. Army Medical Research and Materiel ...

We report on two classes of autoequivalences of the category of Yetter-Drinfeld modules over a finite group, or, equivalently the Drinfeld center of the category of representations of a finite group. Both operations are related to the r-th power operation, with r relatively prime to the exponent of the group. One is defined more generally for the group-theoretical fusion category defined by a f...

Counter automata are more powerful versions of finitestate automata where addition and subtraction operations are permitted on a set of n integer registers, called counters. We show that the word problem of Zn is accepted by a nondeterministic m-counter automaton if and only if m ≥ n.

We invoke a neo-Foucauldian model of the panoptic gaze to understand the practices of military visuality and of newly emerging efforts to resist and subvert deep-seated and long-held governmental secrecy over military/intelligence activities and their sites of operation. The case studies set out in the second half of the paper are attempts question excessive secrecy underlying the military pano...

the main purpose of this article is studing un’s actions to counter international terrorism giving to development of it after cold war.we are going to answer the question in descriptive-analtical way that what was un’s practical actions to counter it and weather it was successful.to answer the main question of this article first we will diccuss the development of terrorism after cold war and ne...

This paper presents efflux time experiments performed in the absence and presence of aqueous solutions of Drag Reducing Agents (DRAs) when a liquid is emptied from a large open cylindrical storage tank through an exit piping system. The drag reducing agents studied are Dodecyl benzene sulfonate anionic surfactant and a mixed solution of surfactant and sodium chloride counter ion. The variab...

pioneering in a dynamic environment is among the issues which most of the organizations, especially knowledge-based institutions will encounter. for using and exploiting the opportunities and also for overcoming threats, there should exist some innovations in the modern technologies domain. therefore, for fulfilling this important issue, organizations are required to monitor inside and outside ...

introduction: studies have indicated that emotional intelligence is positively related to self-efficacy and can predict the academic achievement. the present study aimed to investigate the role of emotional intelligence in identifying self-efficacy among the students of public health school with different levels of academic achievement. methods: this correlational study was conducted on all the...

We consider lossy counter machines, i.e. counter machines with counters whose contents can spontaneously decrease at any time. They are not Turing-powerful, since reachability is decidable for them, but they still have interesting undecidable properties: For a lossy counter machine it is undecidable if there exists an initial connguration s.t. there is an innnite run. Lossy counter machines can...