BACKGROUND The study objective was to evaluate the role of transesophageal echocardiography in identifying the origin of anomalous coronary arteries and confirming their course in relation to the great vessels. The diagnosis of coronary anomalies is made by angiography. The anomalous left main artery with a course between the pulmonary artery and the aorta has been associated with myocardial in...

The effects of altering the site of electrical activation on responses to isoproterenol (ISO) and treadmill exercise were examined in mongrel dogs instrumented for long-term measurement of left ventricular pressure, left ventricular dP/dt, coronary blood flow, cardiac output, left ventricular diameters, and mean arterial pressure and O2 content in the coronary sinus and aorta. During spontaneou...

BACKGROUND AND OBJECTIVES Many clinicians believe that low-dose dopamine (LDD) [2 micro g/kg/min] increases renal blood flow (RBF) and medium-dose norepinephrine (MD-NE) [0.4 micro g/kg/min] decreases RBF. They also believe that MD-NE might induce mesenteric and/or coronary ischemia. In fact, the effects of these drugs on renal and vital organ blood flow are poorly understood. The aim of this s...

cocaine is used by more than 14 million people worldwide, about 0.3 percent of the global population age is 15 to 64 years. after alcohol, cocaine is the most common cause of acute drug-related emergency department visits in the united states. cocaine consumption is more frequently associated with acute cardiovascular illness.  cocaine stimulates α 1 , α 2 , β 1 and β 2 adrenergic receptors thr...

Using a constant infusion of two indicators, T-1824 bound to albumin and tritiated water, flow and transit time were measured in the left coronary system of intact man. Indicators were infused for 6 minutes into the left coronary artery with sampling from the coronary sinus in a region that drained exclusively the inflow of the left coronary artery and from the brachial artery for recirculation...

Q measurement of coronary blood flow by indicator-dilution methods has been attempted by various groups within the past five years. The theory upon which these studies have been based is that after injection into either the pulmonary artery or left ventricle, the first activated blood to reach the right ventricle on recirculation returns by way of the coronary vessels. Henly and eo-workers rapi...

Background and objectives: Many clinicians believe that low-dose dopamine (LDD) [2 g/kg/min] increases renal blood flow (RBF) and medium-dose norepinephrine (MD-NE) [0.4 g/kg/min] decreases RBF. They also believe that MD-NE might induce mesenteric and/or coronary ischemia. In fact, the effects of these drugs on renal and vital organ blood flow are poorly understood. The aim of this study was to...

INTRODUCTION Alongside the remarkable progress in therapeutic strategies destined to patients with coronary artery disease (CAD), a growing number of patients who suffer from severe and diffuse CAD not amenable for revascularization, continue to experience severe debilitating angina despite optimal medical therapy. The Coronary Sinus (CS) Reducer has emerged as a novel therapeutic strategy for ...

Methods Thirteen CSX patients (64 ± 12SD years, 9 females), here defined as a history of chest pain and pathological ECG reaction during stress (> 1 mm ST-depression at stress or after 4 minutes of recovery) but normal myocardial perfusion assessed by myocardial perfusion scintigraphy (SPECT), were included. In addition, 15 positive controls (66 ± 9SD years, 6 females) with stress-induced perfu...

Objective—Introduction and measurement of human myocardial oxygen supply:demand ratio as a reference for quantification of coronary microvascular vasodilating drug effects in clinical studies. Myocardial oxygen consumption is the major determinant of coronary blood flow; therefore, the true vasodilating properties of coronary vasodilating drugs that may have an effect on oxygen consumption cann...