Connective Tissue Growth Factor (CTGF) and Transforming growth factor-β1 (TGF-β1) are key growth factors in regulating corneal scarring. Although CTGF was induced by TGF-β1 and mediated many of fibroproliferative effects of TGF-β1, the signaling pathway for CTGF production in corneal scarring remains to be clarified. In the present study, we firstly investigated the effects of c-Jun N-terminal ...

PURPOSE We investigated the association between corneal hysteresis (CH) and corneal resistance factor (CRF) with glaucoma severity in primary angle closure glaucoma (PACG). METHODS We recruited 204 subjects with PACG. Each subject underwent CH and CRF measurements using the Ocular Response Analyzer (ORA), optic nerve head topography measurement using scanning laser ophthalmoscopy, and visual ...

purpose : to present the clinical features, biomechanical properties and management of a patient who developed unilateral corneal ectasia after photorefractive keratectomy (prk) case report : the patient was a 24-year-old man without any obvious preoperative risk factor for ectasia who underwent bilateral prk. four years after keratorefractive surgery, the patient presented with loss of visual ...

Background & Aims: This study was carried out to determine the leading indications for corneal transplantation in Kerman province. Methods: Medical records of 186 patients underwent corneal transplantation during 3 years (2004-2006) in Shafa Medical Center were evaluated retrospectively. The initial diagnosis and causes of corneal grafting were recorded. Infectious keratitis (Bacterial, Fungal,...

The major cause of corneal opacity and resultant visual loss is a critical decrease in corneal endothelial cell density. Due to the fact that corneal endothelial cells do not generally proliferate, cell densities gradually decrease in the corneal endothelium with age. Before we can begin to aid patients with decreasing endothelial cell densities, by inhibiting cell death or stimulating cell pro...

We tested the effects on laser ablation of reflection losses and nonnormal incidence on the anterior cornea. We measured presurgical and postsurgical corneal asphericity in 94 myopic eyes, comparing it with the corneal asphericity predicted by the Munnerlyn formula, modified or not, with an adjustment factor that takes into account the two effects mentioned above. The predictive power of the ex...

The electrical potential difference and electrical resistance of the nonswelling cornea of the dogfish, Squalus acanthias, were examined. It was found that routine procedures used in the procurement of fish invariably produce damage to the corneal epithelium which affects electrical measurements and possibly composition of the aqueous humor. We found no electrical evidence of ionic pumps in the...

PURPOSE This experiment aims to investigate the potential ability of mesenchymal stem cells (MSCs) to produce beneficial factors for corneal recovery when the cells were seeded on a xenogeneic acellular corneal matrix (ACM) in vitro. METHODS MSCs and corneal limbal stem cells (LSCs) from the corneal limbus region of rats were isolated and cultured. Batch 1 from each type of cell was seeded on...

Corneal wound healing involves a complex cascade of cytokine-controlled cellular events, including inflammatory and angiogenesis responses that are regulated by transcriptional chromatin remodeling. Nuclear Ubiquitous Casein and cyclin-dependent Kinase Substrate (NUCKS) is a key chromatin modifier and transcriptional regulator of metabolic signaling. In this study, we investigated the role of N...

Introduction In recent years, reduced corneal biomechanics have been identified as an important element in the pathogenesis of various corneal diseases. The biomechanical characteristics of a connective tissue such as strength and resistance against mechanical stress are indispensable prerequisites to maintain regular shape and function of that tissue. Intraand intermolecular cross-links betwee...