P eripheral ulcerative keratitis (PUK) is a devastating complication of rheumatoid arthritis (RA) that can lead to rapid corneal destruction (corneal melt) and perforation with loss of vision (fig 1). It is well reported to herald systemic vasculitis and carries a high mortality rate if not aggressively treated. There is a paucity of information concerning the clinical and serological character...

Singh S, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-221565 Description A 16-year-old male presented with deep dermal burns of upper and lower eyelids and decreased vision in left eye after falling on a hot silencer of a motorcycle 2 weeks before. His best-corrected visual acuity was 6/6 and light perception in right and left eye, respectively. Skin over the left side of the nose, root of th...

INTRODUCTION The harmful effect of the herbal medicine to the eye has not been well reported in the literature. OBJECTIVE To report a case of bilateral corneal perforation following the use of traditional herbal medicine treated with conjunctival flap. CASE A 46-year-old Fijian man initially presented with bilateral conjunctivitis, which was thought to be an allergic response to the use of ...

Evidence suggests that Pseudomonas aeruginosa stromal keratitis and corneal perforation (susceptibility) is a CD4(+) T cell-regulated inflammatory response following experimental P. aeruginosa infection. This study examined the role of Langerhans cells (LC) and the B7/CD28 costimulatory pathway in P. aeruginosa-infected cornea and the contribution of costimulatory signaling by this pathway to d...

We compared the clinical presentation and treatment outcomes of corneal and scleral perforations in geriatric nursing home residents, geriatric community residents, and non-geriatric population. The medical records of patients who were treated for corneal and scleral perforations at the Prince of Wales Hospital, Hong Kong between January 1, 2004 and May 1, 2013, were reviewed retrospectively. O...

BACKGROUND Herpes Simplex Virus (HSV) keratitis is a leading cause of corneal blindness. Definitive laboratory diagnosis is essential for timely management. Collection of corneal scrapings in patients with advanced epithelial keratitis and corneal thinning poses perforation risks; tear fluid is a feasible and convenient alternative but has not been widely evaluated for HSV detection. METHODS ...