The need for tools to aid the description and sharing of biological models was highlighted at the launch of the International Union of Physiological Sciences Physiome Project in 1997. This has resulted in the release, in 2001, of the CellML specifications (http://www.cellml.org/specifications/). CELLULAR OPEN RESOURCE (COR) was among the early adopters of this standard, eventually forming the f...

C ancer cells become far more dangerous when they gain the ability to metastasize and colonize other parts of the body. But to start moving, the rogue cells have to break away from their neighbors. Walter Birchmeier (now at the Max-Delbrück-Center of Molecular Medicine in Berlin, Germany) and colleagues discovered how, showing that some cancer cells down-regulate a surface receptor that locks a...

___________ _ This paper describes a diagnosis of and surgical treatment of Cor Triatriatum Dextrum in a term baby who, six hours postpartum, was determined to be cyanotic. The diagnosis was reached using twodimensional echocardiography and angiocardiography. This case is the second diagnosis of cor triatriatum dextrum made during the first day of life, and the first successful surgery of this ...

The Research Institute for Cognition and Robotics (CoR-Lab) combines research activities at Bielefeld University in the areas of cognition and intelligent robotics and a strategic cooperation with Honda Research Institute Europe GmbH (HRI-EU). HRI-EU contributes support for PhD students in the CoR-Lab’s graduate school and provides two humanoid robots ASIMO together with the operating software ...

Transcriptional repression mediated by corepressors N-CoR and SMRT is a critical function of nuclear hormone receptors, and is dysregulated in human myeloid leukemias. At the present time, these corepressors are thought to act exclusively through an mSin3/HDAC1 complex. Surprisingly, however, numerous biochemical studies have not detected N-CoR or SMRT in mSin3- and HDAC1-containing complexes. ...

Transcriptional repression plays crucial roles in diverse aspects of metazoan development, implying critical regulatory roles for corepressors such as N-CoR and SMRT. Altered patterns of transcription in tissues and cells derived from N-CoR gene-deleted mice and the resulting block at specific points in CNS, erythrocyte, and thymocyte development indicated that N-CoR was a required component of...

The Calculus of Reenements (COR) presented here takes this idea of types as spec-iications and subtyping as reenement and pushes it to an extreme. Types and values are no longer distinguished; in COR we consider a unique hierarchy of objects. A good way to deal with the hierarchy of objects is to structure it as a complete lattice. And if functions are to be considered as rst class citizens in ...

Introduction: The incidence of cor triatriatum among neonates with congenital heart disease is only 0.1% to 0.4%. The diagnosis in adults is extremely rare. Case: A 68 years old patient was referred to our cardiovascular surgery department following transthoracic echocardiography and a diagnosis of cor triatriatum. Echocardiography was performed due to stroke and atrial fibrillation. Echocardio...

Introduction. Cor triatriatum is a rare congenital heart disease found incidentally in children. Although cor triatriatum can be an incidental finding in asymptomatic adults; it is extremely rare to find elderly patients without symptoms and is unique in a long distance runner. Case Presentation. We present the case of an 83-year-old long-distance runner with cor triatriatum sinistrum and atria...

Integrating the expanding job embeddedness (JE) literature, in this article we advance a multifoci model of JE that is theoretically grounded in conservation of resources (COR) theory. From COR theory, we posit that employees' motivation to acquire and protect resources explains why they become embedded and how they behave once embedded. Our COR-based JE model highlights contextual antecedents ...