BACKGROUND While copper has essential functions as an enzymatic co-factor, excess copper ions are toxic for cells, necessitating mechanisms for regulating its levels. The cusCBFA operon of E. coli encodes a four-component efflux pump dedicated to the extrusion of Cu(I) and Ag(I) ions. METHODOLOGY/PRINCIPAL FINDINGS We have solved the X-ray crystal structure of CusC, the outer membrane compone...

dear editor: sir, the present public health problem to be concerned is the e. coli outbreak in europe. this problem started in germany and extended widely. the main presentation of e. coli infection is diarrhea. however, the other non-diarrhea symptoms are also mentioned. focusing on eye manifestations, the conjunctivitis is a topic to be focused. indeed, e. coli is confirmed as an important ca...

objective(s) extensive use of quinolones has been associated with raising level of resistance. in the current, we focused on assessing the prevalence of escherichia coli resistance to quinolones and frequency of qnra, qnrb and qnrs in non esbls (extended spectrum beta-lactamases) and esbls producing e. coli with blashv and blatem. materials and methods one hundred and fifty e. coli isolates wer...

introduction: extended spectrum beta-lactamase (esbl) producing escherichia coli generate a major problem for clinical therapeutics and epidemiological study. the incidence of esbl producing strains among clinical isolates has been steadily increasing during the past few years, and remains an important cause of failure of therapy with cephalosporins. the aim of this study was to determine the a...

a variety of probiotic bacteria have been tested to control animal and foodborne pathogenic bacteria in livestock. the mechanism of inhibition of pathogenic bacteria for several of those probiotic microorganisms is mediated by the production of bacteriocins. colicins are probably the group of bacteriocins that have been most thoroughly characterized. colicins are antimicrobial proteins produced...

Background: Escherichia coli is a commensal-pathogenic organism, which includes a wide range of strains. Despite several advanced molecular-genomic technologies for detecting and identifying different strains of E. coli, Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction (ERIC-PCR) technique is ...

Escherichia coli (E. coli) bacteria can damage DNA of the gut lining cells and may encourage the development of colon cancer according to recent reports. Genetic switches are specific sequence motifs and many of them are drug targets. It is interesting to know motifs and their location in sequences. At the present study, Gibbs sampler algorithm was used in order to predict and find functional m...

The title of this article may seem abrasive, but the stakes are human lives that affected by E. coli infections and drinking water contaminations lead copper. First all, research targets a new urgent understanding common cause for outbreaks, which results in many illnesses deaths every year. As part world-wide problem, infects more than 73,000 people kills 60 year U.S. alone. Also connection ex...

shiga toxin producing escherichia coli have been associated with hus, hc and ttp in human. we found recto-anal mucosal sample in sheep as well in cattle is the main site for e. coli o157 localization. 1246 e. coli isolates from 872 both healthy and diarrheic animals were analyzed, by screening for the presence of shiga toxin-producing (vt 1 and vt 2) and intimin (eae) genes used multiplex pcr. ...

Nanotechnology is a new and specific method for therapy of diseases. Nanosilver particle is one of the functional fields of nanotechnology. It has been shown that these nanoparticles have antibacterial and antifungal properties. Different studied have been shown that nanoparticles may have important role in medicine. For example, it has been shown to have inhibitory effects on the treatment of ...