Background: Therapeutic interchange is widely used in geriatric settings, such as angiotensin enzyme converting inhibitors and angiotensin II receptor antagonists and angiotensin receptor blockers (sartans). Objective: we evaluate the clinical impact (efficacy and tolerance) of a therapeutic interchange program for noncomplicated hypertension. Method: 13 patients receiving angiotensin enzyme co...

Angiotensin receptor blockers are usually considered as equivalent to angiotensin converting enzyme inhibitors for patients with heart failure and low-ejection fraction. Some guidelines even recommend the former as first line treatment given their better adverse effects profile. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified four systematic rev...

Pemphigoid diseases are a group of blistering autoimmune pathologies including pemphigus vulgaris (PV) and foliaceous, which affect mucocutaneous tissues. Non-steroidal anti-inflammatory drugs, penicillamine, angiotensin-converting enzyme inhibitors such as captopril enalapril associated with drug-induced pemphigoid. We present case lisinopril-associated PV has not been previously reported.

OBJECTIVE To determine the effect of combinations of statins, aspirin, beta blockers, and angiotensin converting enzyme inhibitors in the secondary prevention of all cause mortality in patients with ischaemic heart disease. DESIGN Open prospective cohort study with nested case-control analysis. SETTING 1.18 million patients registered with 89 general practices across 23 strategic health aut...

diabetic retinopathy is the leading cause of blindness in the world. strict control of blood sugar, blood pressure, laser therapy, pharmacotherapy and vitrectomy are of among common diabetic retinopathy treatments. further studies to investigate the effect of protein kinase c inhibitors, angiotensin converting enzyme inhibitors, growth hormone and other proposed treatments for diabetic retinopa...

The angiotensin-converting enzyme from rabbit lung was purified to a homogeneous protein. The molecular weight of the enzyme or its subunits in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was established as 180,000. Converting enzyme contained about 8% (w/w) hexoses (based on glucose). The K,,, values for the hydrolysis of angiotensin I and [desAspllangiotensin I by the purified e...

Bilateral renal artery stenosis (RAS) causing recurrent hypertensive emergency and pulmonary oedema is difficult to manage. Use of angiotensin converting enzyme inhibitors (ACEi) II receptor blockers (ARB) usually contraindicated. We present a systematic review literature case vignette which highlights the useful properties this mineralocorticoid antagonists (MRAs) in scenario.

INTRODUCTION The results of large clinical studies indicate that angiotensin-converting enzyme (ACE) inhibitors are effective agents in patients with coronary artery disease (CAD), even if their blood pressure is within normal limits. MATERIAL AND METHODS In the present study, we compared the effect of plasma- and tissue-type angiotensin-converting enzyme inhibitors on plasma levels of leptin...