Sixteen patients with persistent (n = 11) or recurrent (n = 5) variceal bleeding after injection sclerotherapy and balloon tamponade were treated with an intravenous infusion of somatostatin 250 micrograms/h. Somatostatin infusion successfully controlled the bleeding in 15 of the 16 patients but one rebled after 72 h of treatment. In one patient with poor liver function (Child's C) bleeding was...

PURPOSE Controversial data about the effect of smoking on the dose-requirements and the pharamcodynamics of rocuronium have been reported recently. This study was conducted to evaluate the dose-requirements and the pharmacodynamics of rocuronium in smokers using target controlled infusion. METHODS The dose-requirements of rocuronium for 60 min relaxation, using target controlled infusion, giv...

BACKGROUND Awake fibreoptic intubation (AFOI) is a technique used in patients with difficult airways. This study compares the suitability of remifentanil target-controlled infusion (TCI) to propofol TCI for conscious sedation during AFOI in patients with bona fide difficult airways. METHODS We recruited 24, ASA I-III patients, who were undergoing sedation for elective AFOI. Patients were rand...

Several propofol infusion platforms have been devised to address the inherent safety problems associated with propofol administration. Patient-controlled and target-controlled infusion systems have been described in the literature, and the Sedasys closed-loop feedback system is in FDA review. No matter what the infusion platform, there are important safety concerns that should be addressed when...

BACKGROUND Acute kidney injury (AKI) is observed in up to 41% of patients undergoing transcatheter aortic valve implantation (TAVI) and is associated with increased risk for mortality. The aim of the present study is to evaluate whether furosemide-induced diuresis with matched isotonic intravenous hydration using the RenalGuard system reduces AKI in patients undergoing TAVI. METHODS/DESIGN Re...

Introduction Atrial natriuretic peptide (ANP), a hormone secreted from the heart, controls cardiovascular and renal functions including arterial blood pressure natriuresis. ANP also exerts metabolic effects in adipose tissue, liver skeletal muscle, interacts with secretion of adipokines. We tested hypothesis that lowers concentrations anorexigenic adipokine leptin healthy humans vivo . Methods ...

Our anesthetic technique proposed for awake craniotomy is the monitored anesthesia care (MAC) technique, with patient in sedation throughout intervention. protocol involves analgo-sedation through administration of dexmedetomidine and remifentanil a continuous intravenous infusion, allowing to be sedated comfort, but contactable spontaneously breathing. Pre-surgery, pre-medicated intramuscular ...

BACKGROUND Continuous passive motion after major knee surgery optimizes the functional prognosis but causes severe pain. The authors tested the hypothesis that postoperative analgesic techniques influence surgical outcome and the duration of convalescence. METHODS Before standardized general anesthesia, 56 adult scheduled for major knee surgery were randomly assigned to one of three groups, e...

Abstract Background The unprecedented efficacy of chimeric antigen receptor T (CAR-T) cell immunotherapy CD19 + B-cell malignancies has opened a new and useful way for the treatment malignant tumors. Nonetheless, there are still formidable challenges in field CAR-T therapy, such as biodistribution cells vivo. Methods NALM-6, human acute lymphoblastic leukemia (B-ALL) line, was used target cells...