Abstract This chapter identifies the policy changes, trends, and debates in years 1995–2008 pivotal to understanding neoliberal foundations of fundraising Canada. Neoliberal restructured relationship government nonprofit voluntary sector by making funding scarce conditional on winning short-term contracts. New representatives did not contest these changes but sought consensus-oriented partnersh...

Biologically active molecules can be identified through the screening of small-molecule libraries. Deficiencies in current compound collections are evidenced by the continuing decline in drug-discovery successes. Typically, such collections are comprised of large numbers of structurally similar compounds. A general consensus has emerged that library size is not everything; library diversity, in...

Although anycast communication supports service– oriented addresses many of its current definitions in IPv6 are unclear. Furthermore, since there are no protocol standards or even consensus on routing control, inter–segment anycast communications are not yet available. In this paper, we first discuss these problems and solutions. Based on our findings, we present the Anycast Address Resolving P...

In January of 1997, Health Level Seven (HL7) began developing Version 3.0 of its standard. The Version 3 effort represents a transformation of the way that HL7 and its Technical Committees will develop future HL7 information interchange standards. This transformation involves applying object-oriented modelling to the development and specification of information interchange standards. This paper...

The cytoplasmic membrane protein TonB spans the periplasm of the Gram-negative bacterial cell envelope, contacts cognate outer membrane receptors, and facilitates siderophore transport. The outer membrane receptor FhuA from Escherichia coli mediates TonB-dependent import of ferrichrome. We report the 3.3 angstrom resolution crystal structure of the TonB carboxyl-terminal domain in complex with ...

Each scientific development that claims to provide a “new way” for approaching existing problems needs proper (i.e. formal and quantifiable) evaluation methods and consensus-based criteria for measuring the validity of its claims. Taken together, these methods and criteria constitute the metrics by which new developments are being measured against their claims. Various claims have been made in ...

A classical peptide inhibitor of serine proteases that is hydrolyzed approximately 10(7) times more slowly than a good substrate is shown to form an acyl-enzyme intermediate rapidly. Despite this quick first step, further reaction is slowed dramatically because of tight and oriented binding of the cleaved peptide, preventing acyl-enzyme hydrolysis and favoring the reverse reaction. Moreover, th...

This practice guideline on gestational diabetes is a treatment oriented short version of the evidence based guideline that can be viewed in the internet. It replaces the DDG and DGGG recommendations of 2001 for diagnostic and therapy of gestational diabetes. A complete rework had become necessary in view of epidemiologically based diagnostic criteria, which had been derived from the Hyperglycae...

Although widely used, the term repellency needs to be employed with care when applied to ticks and other periodic or permanent ectoparasites. Repellency has classically been used to describe the effects of a substance that causes a flying arthropod to make oriented movements away from its source. However, for crawling arthropods such as ticks, the term commonly subsumes a range of effects that ...

Abstract There is a broad consensus on the importance and advisability of testing laboratories adopting Quality Management System (QMS) to support their work, no matter they are industrial or research oriented. However, involved in R&D have specific difficulties implement QMS due peculiar nature activity. This paper analyzes main challenges found by professionals when implementing laborator...