Functional neuroimaging (e.g., with fMRI) has been difficult to perform in mice, making it challenging to translate between human fMRI studies and molecular and genetic mechanisms. A method to easily perform large-scale functional neuroimaging in mice would enable the discovery of functional correlates of genetic manipulations and bridge with mouse models of disease. To satisfy this need, we co...

The deceptively simple laminar structure of neocortex belies the complexity of intra- and interlaminar connectivity. We developed a computational model based primarily on a unified set of brain activity mapping studies of mouse M1. The simulation consisted of 775 spiking neurons of 10 cell types with detailed population-to-population connectivity. Static analysis of connectivity with graph-theo...

Given the sensitivity of the potential WSN applications and because of resource limitations, key management emerges as a challenging issue for WSNs. One of the main concerns when designing a key management scheme is the network scalability. Indeed, the protocol should support a large number of nodes to enable a large scale deployment of the network. In this paper, we propose a new scalable key ...

Very little is currently known about the cerebral characteristics that underlie the complex processes of meditation as only a limited number of studies have addressed this topic. Research exploring structural connectivity in meditation practitioners is particularly rare. We thus acquired diffusion tensor imaging (DTI) data of high angular and spatial resolution and used atlas-based tract mappin...

Motion planning is the problem of computing valid paths through an environment. However, because computing exact solutions is intractable, sampling-based algorithms, such as Probabilistic RoadMaps (PRMs), have gained popularity. PRMs compute an approximate mapping of the planning space by sacrificing completeness in favor of efficiency. However, these algorithms have certain bottlenecks that hi...

Given the sensitivity of the potential WSN applications and because of resource limitations, key management emerges as a challenging issue for WSNs. One of the main concerns when designing a key management scheme is the network scalability. Indeed, the protocol should support a large number of nodes to enable a large scale deployment of the network. In this paper, we propose a new scalable key ...

The ability to map functional connectivity is necessary for the study of the flow of activity in neuronal circuits. Optical imaging of calcium indicators, including FRET-based genetically encoded indicators and extrinsic dyes, is an important adjunct to electrophysiology and is widely used to visualize neuronal activity. However, techniques for mapping functional connectivities with calcium ima...

Diffusion tensor imaging (DTI) is a neuroimaging MR technique, which allows in vivo and non-destructive visualization of myeloarchitectonics in the neural tissue and provides quantitative estimates of WM integrity by measuring molecular diffusion. It is based on the phenomenon of diffusion anisotropy in the nerve tissue, in that water molecules diffuse faster along the neural fibre direction an...

In this fMRI study, we explore the connectivity among brain regions in a shape-from-motion task using the causal mapping analysis of structural equation modeling (SEM). An important distinction of our approach is that we have adapted SEM from its traditional role in confirmatory analysis to provide utility as an exploratory mapping technique. Our current approaches include (I) detecting brain r...

A laboratory-generated hierarchical, fully heterogeneous aquifer model (FHM) provides a reference for developing and testing an upscaling approach that integrates large-scale connectivity mapping with flow and transport modeling. Based on the FHM, three hydrostratigraphic models (HSMs) that capture lithological (static) connectivity at different resolutions are created, each corresponding to a ...