One of the effective approaches to develop new anticancer drugs is to prepare polymeranticancer drug conjugates. The polymer-anticancer drug conjugates include polymerprotein conjugates, polymer-drug conjugates and supramolecular drug-delivery systems. In 1975, the concept of a polymer-drug conjugate was first proposed by Ringsdorf (Ringsdorf, 1975). In his model, a bioactive anticancer agent w...

Numerical identification of diffusion parameters in a nonlinear convection–diffusion equation is studied. This partial differential equation arises as the saturation equation in the fractional flow formulation of the two–phase porous media flow equations. The forward problem is discretized with the finite difference method, and the identification problem is formulated as a constrained minimizat...

A method was developed for determining the composition of the conjugates between gold nanoparticles and proteins based on the intrinsic fluorescence of unbound protein molecules. The fluorescence was evaluated after separation of the conjugates from the reaction mixture by centrifugation. Gold nanoparticles obtained using the citrate technique (average diameter 24 nm) were conjugated at pH 5.4 ...

To generate antibodies against small molecules, it is necessary to couple them as haptens to large carriers such as proteins. However, the immunogenicity of the conjugates usually has no linear correlation with the hapten-protein ratio, which may lead to large variations in the character of the desired antibodies. In the present study, ciprofloxacin (CPFX) was coupled to bovine serum albumin (B...

1. This note summarizes a paper [4] to appear in full elsewhere. It presents an algorithm for the minimization of a general (not necessarily differentiable) convex function. Its central idea is the construction of descent directions as projections of the origin onto the convex hull of previously calculated subgradients as long as satisfactory progress can be made. Using projection to obtain a d...

in the present investigation efforts have been made to synthesis polyvinyl pyridine (pvpy) /c60 conjugatesthrough 2, 2-azobisisobutyronitrile (aibn) initiated insitu polymerization of pvpy in scco2.the processof synthesis was monitored under different reaction conditions ranging 1200-1800psi, 60-90 oc over 6hours. the progress of polymerization was monitored rheoviscometrically. the concentrati...

In this paper we address the issue of recognizing Farsi handwritten words. Two types of gradient features are extracted from a sliding vertical stripe which sweeps across a word image. These are directional and intensity gradient features. The feature vector extracted from each stripe is then coded using the Self Organizing Map (SOM). In this method each word is modeled using the discrete Hidde...